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Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition

a technology of electrical stimulation and brain tissue, applied in the field of electrical stimulation, can solve the problems of direct medical and other benefit costs, reduce productivity, and direct medical and other benefits, and achieve the effect of reducing or eliminating certain problems and disadvantages

Inactive Publication Date: 2006-01-05
ADVANCED NEUROMODULATION SYST INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides an electrical stimulation system for treating neurological conditions by stimulating target tissue in a person's brain. The system includes an electrode implanted in the skull for electrical stimulation of the brain. The system can modulate the activity of certain brain regions to treat various neurological disorders such as pain, phantom pain, and movement disorders. The invention has advantages over previous techniques for treating neurological conditions, such as reducing or eliminating certain problems associated with previous methods. The invention can also be used to enhance or decrease certain neurological or psychiatric functions, such as alertness, conscious state, drive, fear, anger, anxiety, and memory disorders.

Problems solved by technology

Chronic pain afflicts approximately 86 million Americans and it is estimated that United States business and industry loses about $90 billion dollars annually to sick time, reduced productivity, and direct medical and other benefit costs due to chronic pain among employees.
For a subset of patients, however, these therapies are inefficacious and more invasive procedures such as blocks, neurolysis and ablative procedures become the only options for treatment.
Such procedures, however, have the fundamental limitation of being inherently irreversible and being essentially a “one-shot” procedure with little chance of alleviating or preventing potential side effects.
In addition, there is a limited possibility to provide continuous benefits as the pathophysiology underlying the chronic pain progresses and the patient's symptoms evolve.
Therefore, despite previous attempts to alleviate the symptoms of chronic pain by deep brain or cortical stimulation, there is still an unmet need for a method of treating chronic pain that is effective in a larger subset of the patient population.

Method used

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  • Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition
  • Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition
  • Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition

Examples

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Effect test

example 1

Treatment of Deafferentation Pain

[0138] In general, patients with intractable deafferentation pain were selected for neuronavigated transcranial magnetic stimulation (TMS) of the somatosensory cortex.

[0139] Prior to TMS a fMRI of the somatosensory cortex was performed demonstrating the area of reorganization. A fMRI was performed, applying tactile stimulation at the deafferented area, inducing hyperalgesia / allodynia. The FMRI demonstrated an area of hyperactivity on the contralateral primary / secondary somatosensory cortex.

[0140] TMS was used to verify the potential benefit of electrical stimulation of the somatosensory cortex. Subsequently a TMS was performed by means of fMRI based neuronavigation (Treon, Medtronic) at 90% motor threshold (MT). If pain suppression was obtained, placebo stimulation at the same site was performed. Stimulation at 110% MT was also tested to exclude motor cortex involvement. The pain suppression obtained by TMS was transient.

[0141] Five of the 8 pati...

example 2

Treatment of Pain

Patient History

[0144] A 53 year old woman presented with a 10 year history of persistent lancinating pain in the right supraorbital region. The pain arose a few weeks after a surgical excision of basocellular carcinoma on the right forehead. Initially she suffered a normal post operative pain progressively evolving to a constant, sharp lancinating pain. Multiple surgical procedures followed with aggravation of the symptoms.

[0145] Except for the pain she also developed a sensation of her right eye being located on her right maxillary arc. Despite a normal vision as demonstrated by an extensive neuro-ophthalmological work-up, the phantom sensation often induced a misperception of the position of surrounding objects causing her to run into obstacles ipsilateral to the phantom sensation.

Clinical Examination

[0146] A hyperalgesia and a loss of sensation of temperature and vibration in the right VI dermatoma were noted. Tactile stimulation of the medial cornea and u...

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PUM

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Abstract

According to one aspect, a stimulation system is provided for electrically stimulating a predetermined site to treat a neurological condition. The system includes an electrical stimulation lead adapted for implantation in communication with a predetermined site, wherein the site is brain tissue site. The stimulation lead includes one or more stimulation electrodes adapted to be positioned in the predetermined site. The system also includes a stimulation source that generates the stimulation pulses for transmission to the one or more stimulation electrodes of the stimulation lead to deliver the stimulation pulses to the predetermined site to treat a neurological disorder or condition.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims priority to U.S. Provisional Application No. 60 / 552,674 filed Mar. 11, 2004, which is incorporated herein by reference in its entirety.TECHNICAL FIELD [0002] This invention relates generally to electrical stimulation of a person's brain and in particular to an electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition, for example pain. BACKGROUND OF THE INVENTION [0003] Many people experience adverse conditions associated with functions of the cortex, the thalamus, and other brain structures. Such conditions have been treated effectively by delivering electrical energy to one or more target areas of the brain. One method of delivering electrical energy to the brain involves inserting an electrical stimulation lead through a burr hole formed in the skull and then positioning the lead in a precise location proximate a target area of the brain to be stimulated suc...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N1/18A61N1/05A61N1/36
CPCA61N1/0529A61N1/0531A61N1/0551A61N1/36071A61N1/361A61N1/3606A61N1/36082A61N1/36067A61N1/36096
Inventor DE RIDDER, DIRK
Owner ADVANCED NEUROMODULATION SYST INC
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