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Method and system for quantitatively analyzing biological samples

Inactive Publication Date: 2005-06-23
VENTANA MEDICAL SYST INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such analysis is, necessarily, based on subjective, human interpretation and is subject to human error.
Currently, pathologists must rely on manually analyzed samples without the benefit of any software tool.
There are limits, however, to the power of the human eye.
Fatigue, repetitiveness of the task, large numbers of cells inside a given sample can be a problem for pathologists, as can the inability to distinguish between similar colors.
Looking for a single object within a range of objects of similar but different sizes and orientations is very difficult.
Additionally, to find the object when it is partially obscured or broken further increases the complexity.
Having a person spend a long period of time scanning slides that have similar features leads to fatigue and increases the chance of missing important information in the slides.

Method used

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  • Method and system for quantitatively analyzing biological samples
  • Method and system for quantitatively analyzing biological samples
  • Method and system for quantitatively analyzing biological samples

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Embodiment Construction

Exemplary Biological Sample Analysis System

[0028]FIG. 1 is a block diagram illustrating an exemplary biological sample analysis processing system 10. The exemplary biological sample analysis processing system 10 includes, but is not limited to, one or more computers 12 with a computer display 14. The computer display 14 presents a windowed graphical user interface (GUI) 16 with multiple windows to a user. The one or more computers 12 may be replaced with client terminals in communications with one or more servers, a personal digital / data assistant (PDA), a laptop computer, a mobile computer, an Internet appliance, one or two-way pagers, or other similar mobile or hand-held electronic device.

[0029] The one or more computers are associated with one or more databases 18 (one of which is illustrated) includes biological sample information in various digital image or digital data formats. The one or more databases 18 may be integral to a memory system on the computer 12 or in secondar...

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Abstract

A method and system analyzing tissue or cell samples stored on laboratory slides or other media to identify properties of medical predictive and diagnostic relevance. The method and system includes automatically analyzing plural digital images created from plural biological tissue samples to which a staining reagent or a an immunohistochemical (IHC) compound has been applied, automatically quantitatively analyzing the relevant properties of the digital images, and creating interpretive data, images and reports resulting from such analysis.

Description

CROSS REFERENCES TO RELATED APPLICATIONS [0001] This patent application claims priority to U.S. Provisional Patent Application No. 60 / 501,142, filed Sep. 10, 2003, and U.S. Provisional Patent Application No. 60 / 515,582 filed Oct. 30, 2003, the contents of both of which are incorporated by reference.FIELD OF THE INVENTION [0002] This invention is related to analysis of laboratory data. More specifically, it relates to a method and system for quantitatively analyzing biological samples. BACKGROUND OF THE INVENTION [0003] Molecular methods are one standard approach used to diagnose and treat a number of diseases. Microarray based (e.g., High Content Screening (HCS)) analysis High Throughput Screening (HTS) analysis and gene expression profiling studies can be used to identify diagnosis markers, analyze disease progression and aid prognosis in developing cures (e.g., cancer progression and tumor analysis). This results in the availability of new and improved diagnostic tests to patients...

Claims

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Application Information

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IPC IPC(8): C12Q1/00C12Q1/68G01N1/30G01N33/48G01N33/50G01N33/53G06F19/00G06T5/00G06T5/40G06T5/50G06T7/00G06V10/46
CPCG01N1/30Y10S128/922G01N33/5091G06F19/345G06K9/00127G06K9/0014G06K9/48G06T7/0012G06T7/0081G06T7/401G06T2200/24G06T2207/10056G06T2207/30024G06T2207/30072G01N33/5005G06T7/11G06T7/41G16H50/20G06V20/69G06V20/695G06V10/46
Inventor GHOLAP, GAURI A.GHOLAP, ABHIJEET S.
Owner VENTANA MEDICAL SYST INC
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