Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition for heart disease, its active ingredients, method to prepare same and uses thereof

a technology for heart disease and composition, applied in the field of composition for heart disease, can solve the problems of unsuitable long-term use, low efficacy, and old manufacturing techniques

Inactive Publication Date: 2005-02-17
TIANJIN TASLY PHARMA CO LTD
View PDF7 Cites 148 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0022] This invention provides the above composition further comprising one or more kinds of excipients, such as polyethylene glycol, xylitol, lactobacillus, starch for preparation of dripping pills, wherein the ratio of weight of the above total extracts or above total pure ingredients to the weight of excipient is 1:1-1:4. For example, 50 mg of Magnesium Salvianolate B, 20 mg of Ginsenoside Rb1, 15 mg of d-Borneol and 265 mg of excipient are contained per ten dripping pills; 20 mg of sodium 3′4-dihydroxyphenyllactate, 20 mg of Ginsenoside Rb1 and 15 mg of d-Borneol and 265 mg of excipient are contained per ten dripping pills.
[0023] The Salvianolate B was extracted by steps of: pulverizing Salvia miltiorrhiza Beg

Problems solved by technology

However, all these drugs have many side effects which make them unsuitable for long-term use.
DST or capsules are still being sold in the market, but their manufacturing techniques are old, their efficacy is low and there are no quality control standards.
The bioavailability is low, and the absorption speed is low, which is not suitable for the emergency treatment of patients with angina pectoris.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0147] 41.06 g of Radix Salviae Miltiorrhizae, 8.03 g of Radix Notoginseng were respectively weighed and ground and then sequentially introduced into an extractor. 5 parts water were added. The mixture was decocted for 2 hours, filtered, and the first filtrate was removed. The residue was added to 4 parts water, decocted for 1 hour, filtered, and then this second filtrate was mixed with the first filtrate. The mixed filtrate was concentrated under decompressed conditions until the solution volume (L) to raw materials weight (Kg) ratio was about 0.9-1.1. 95% ethanol was gradually poured in until the concentration of ethanol was 69-71%. This was settled for 12 hours and filtered. The filtrate, in which ethanol is evaporated, is concentrated to extract of the relative of 1.32-1.40.

[0148] The above extract was mixed with 0.46 g of borneol and 18 g of polyethylene glycol 6000. The mixture was heated to 85° C., melted for 30 minutes, and then transferred to a dropping machine at 80° C. T...

example 2

[0151] 31.12 g of Radix Salviae Miltiorrhizae, 9.21 g of Radix Notoginseng, 0.50 g of borneol and 20 g of polyethylene glycol 6000 were processed according to the extraction and preparation method of Example 1, except for the difference in parameters as follows: the temperature of the dropping machine was 64° C., and the temperature of the liquid paraffin was 0° C.

[0152] The dropping pill is a reddish brown-brownish black sphere with an even size, smooth color, distinct scent, and bitter taste. The weight per pill is 25 mg±15%, and the diameter per pill is 3.34±15% mm.

[0153] The above dropping pill contains the following 5 active ingredients: Sodium 3′4-dihydroxyphenyllactate, Protocatechuic Aldehyde, Salvianolic acid A, B, C, D, E, F, Rosemarinic acid, Ginsenoside Rg1, Ginsenoside Rb1, Ginsenoside Re, Notoginsenoside R1, Borneol, etc.

example 3

[0154] 59.36 g of Radix Salviae Miltiorrhizae, 6.38 g of Radix Notoginseng, 0.34 g of borneol and 21 of polyethylene glycol 6000 were taken and processed according to the extraction and preparation method of Example 1, except for the difference in parameters as follows: the temperature of the dropping machine was 69° C., and the temperature of polymethyl siloxane as condensation liquid was 4° C.

[0155] The dropping pill is a reddish brown-brownish black sphere with an even size, smooth color, distinct scent, and bitter taste. The weight per pill is 25 mg±15%, and the diameter per pill is 3.86±15% mm.

[0156] The above dropping pill contains the following active ingredients: Sodium 3′4-dihydroxyphenyllactate, Protocatechuic Aldehyde, Salvianolic acid A, B, C, D, E, F, Rosemarinic acid, Ginsenoside Rg1, Ginsenoside Rb1, Ginsenoside Re, Notoginsenoside R1, Borneol, etc.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Temperatureaaaaaaaaaa
Temperatureaaaaaaaaaa
Temperatureaaaaaaaaaa
Login to View More

Abstract

This invention provides a composition for heart disease comprising extracts from raw herbs of 80.0-97.0% Radix Salviae Miltorrhizae, 1.0-19.0% Panax Notoginseng and 0.1-1.0% Borneol and its active ingredients. This invention also provides a method for preparing said composition and the active ingredients of the composition. Finally, this invention provides various uses of said compositions and the active ingredients.

Description

[0001] The application disclosed herein claims benefit of U.S. Ser. No. 60 / 491,466, Filed Jul. 31, 2003, the content of which are hereby incorporated in its entirety by reference into this application. [0002] Throughout this application, various publications are referenced and full citations for these publications may be found in the text where they are referenced. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains.BACKGROUND OF THE INVENTION [0003] Heart disease includes a number of conditions affecting the structure or function of the heart. They can include: coronary artery disease, including heart attack, abnormal heart rhythms, heart failure, heart valve disease, congenital heart disease, heart muscle disease or cardiomyopathy, and pericardial disease. [0004] Heart disease is the leading cause of death for both men and women in the United St...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/045A61K36/258A61K36/537
CPCA61K31/045A61K36/258A61K36/537A61K2300/00A61P9/10
Inventor YAN, XIJUNWU, NAIFENGGUO, ZHIXINYE, ZHENGLIANGLIU, YAN
Owner TIANJIN TASLY PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com