Methods for treating arthritic conditions in dogs

Abstract

The present invention relates to a method for eliciting a disease modifying effect on an arthritic condition in a hip or stifle of a canine which comprises administering to the canine a therapeutically effective amount of a bisphosphonate. The present invention also relates to method for eliciting a disease modifying effect on hip dysplasia or stifle instability, the pain associated with hip dysplasia or stifle instability, joint swelling, shallowing of the acetabulum, narrowing of the joint space, subchondral bone sclerosis, preventing osteophyte formation and preventing joint destruction in a canine which comprises administering to the canine a therapeutically effective amount of a bisphosphonate.

Description

Background of the invention [0001] Osteoarthritis (OA) is a degenerative joint disease characterized by pain, cartilage loss, and joint stiffness. It is a common disease affecting dogs of all ages, but is most prevalent in older animals. It can be a primary condition, which is the result of general wear and tear, or a secondary condition, which is the result of an injury, infection, non-union fracture, or developmental abnormality. [0002] Developmental hip disease is a developmental disorder in dogs in which a deformity between the femoral head and the acetabulum creates joint instability that allows excessive movement of the femoral head. This is a common condition in dogs, especially in large breeds. The exact cause is not known, but there is a genetic component. Although the disease may be genetic, the expression of the defect is largely influenced by factors such as nutrition, growth rate, obesity and exercise. [0003] Initially, hip dysplasia was observed as a loss...

AI Technical Summary

Problems solved by technology

Analgesics relieve discomfort but do not treat the underlying condition

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