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Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases

An eye disease and post-treatment technology, which is used in the field of delivering drugs for the treatment of posterior segment diseases, and can solve problems such as the inability of constant doses of drugs to be administered

Inactive Publication Date: 2007-04-11
DIRECTCONTACT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therapeutic treatments also exist, such as those that increase tear production, but effective delivery of these drugs presents the same problems as back-stage drugs
For example, these drugs cannot be given in constant doses for a long time

Method used

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  • Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0070] To exemplify the ability to use hydrogels to deliver drugs to the posterior segment, a trial was designed and a contact lens was used to deliver drugs to the retina. Eyeglasses from each New Zealand white rabbit were treated with VEGF, followed by one eyeglass with prednisolone, leaving the other eyeglass as a control. VEGF is known to cause edema of the retina and prednisolone is known to interfere with this mechanism. The contact lenses were high water ionomer lenses (SOFTLENS 66, Bausch and Lomb, Rocheser, NY) with a water content of approximately 66%. Each lens is about 13mm in diameter.

[0071] Lens Preparation-

[0072] The lenses were dehydrated according to standard manufacturing methods. Lenses were soaked in 1 mg / mL aqueous solution of VEGF (Sigma) for 12 hours at room temperature. Then, to load the lenses with drug, similar lenses were soaked in 1 mg / mL prednisolone in water for 12 hours at room temperature.

[0073] A lens containing VEGF was placed on...

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Abstract

This invention provides articles and methods for drug delivery including a hydrogel containing one or more drugs for the treatment of a posterior segment disease and / or dry eye conditions. Exemplary drugs are anti-angiogenesis compounds for the treatment of macular degeneration. Allowing passive transference of this drug from a dilute solution into the hydrogel produces the delivery system. The hydrogel, when placed in contact with the eye, delivers the drug. The delivery of the drug is sustained over an extended period of time, which is of particular utility in the eye, which is periodically flushed with tears. This sustained delivery accelerates the treatment process while avoiding potential damaging effects of localized delivery of high concentrations of compounds, e.g., from eye drops.

Description

technical field [0001] The present application relates to methods and articles for the treatment of ocular disorders, in particular, it relates to the delivery of drugs for the treatment of posterior segment diseases. Background technique [0002] Diseases of the posterior segment of the eye, also known as back of eye (BOE) diseases, include diseases such as age-related macular degeneration (AMD) and vascular retinopathy. AMD is often classified as one of two types, either "wet" or "dry." Although dry AMD is the most prevalent, the wet form is usually more severe and can lead to blindness. In some cases the dry type can develop to the wet type. There are existing drugs for the treatment of posterior segment disease, and new drugs are being developed and tested. However, delivering drugs to the posterior segment can be difficult, dangerous or painful for a number of reasons. [0003] Systemic and topical (eg, via eye drops) administration of drugs ...

Claims

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Application Information

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IPC IPC(8): A61F2/00
Inventor 克莱德·舒尔茨
Owner DIRECTCONTACT
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