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Chinese medicine eye drops and its making method

A technology of eye drops and traditional Chinese medicine, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of unsatisfactory antibiotic treatment effect, aggravated environmental pollution, and increased eye irritation of drugs , to achieve good demonstration and guiding effects, broad market development prospects, and great clinical therapeutic effects

Inactive Publication Date: 2007-04-04
JINLING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, from the perspective of pharmacy, there are certain problems in the above two methods. For example, Qingkailing injection is used to treat external ocular infectious diseases by intravenous injection, and the result is that the drug concentration in the eye infection site is low. , the curative effect decreases, and at the same time the incidence of adverse reactions such as allergies, rashes, and fever is greatly increased; if Qingkailing injection is used directly in the eyes, although it can maintain a high local drug concentration and improve the curative effect, the drug The irritation to the eyes increases accordingly, and the safety of the clinical use of the drug cannot be guaranteed
[0005] In view of the fact that the long-term and extensive application of antibiotic eye drops has caused bacterial strain resistance and the increasing environmental pollution and many other factors, there is a trend of mixed infection in clinical ocular infectious diseases, and the treatment effect of simple large-scale use of antibiotics is not ideal , therefore, the research and development of Qingkailing eye drops is of great significance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0320] Prescriptions of APIs that constitute the active ingredients:

[0321] Cholic acid 3.25g, mother of pearl (powder) 50g, hyodeoxycholic acid 3.75g, gardenia 25g,

[0322] Buffalo horn (powder) 25g, Radix isatidis 200g, baicalin 5g, honeysuckle 87.5g.

[0323] Prescription of excipients:

[0324] Edetate disodium 5g, vitamin C sodium 10g, methylparaben 2g, propylparaben 1g.

[0325] Total production: 1000 bottles

[0326] Preparation:

[0327] a. Take the raw and auxiliary materials according to the prescription;

[0328] b. Add 12 times the amount of honeysuckle to honeysuckle, decoct twice, 0.5 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.12-1.13 (70°C), add ethanol to make the alcohol content reach 75 %, filter, adjust the pH value of the filtrate to 8.0, refrigerate, filter, recover ethanol from the filtrate and concentrate until the relative density is 1.14-1.15 (70°C), add ethanol to make the alcohol conten...

Embodiment 2

[0336] Prescriptions of APIs that constitute the active ingredients:

[0337] Cholic acid 4g, mother of pearl (powder) 45g, hyodeoxycholic acid 3g, gardenia 20g,

[0338] Buffalo horn (powder) 30g, Radix isatidis 210g, baicalin 4g, honeysuckle 90g.

[0339] Prescription of excipients:

[0340] Edetate disodium 3g, vitamin C sodium 8g, methylparaben 1g, propylparaben 2g.

[0341] Total production: 1000 bottles

[0342] Preparation:

[0343] a. Take the raw and auxiliary materials according to the prescription;

[0344] b. Add honeysuckle to 10 times the weight of honeysuckle, decoct twice for 0.5 hours each time, combine the decoction, filter, and when the filtrate is concentrated to 70°C, the relative density is 1.12-1.13, and ethanol is added to make the alcohol content reach 75 %, filter, adjust the pH value of the filtrate to 7.5, refrigerate, filter, recover ethanol from the filtrate and concentrate it to 70°C, and the relative density is 1.14-1.15, add ethanol to mak...

Embodiment 3

[0352] Prescriptions of APIs that constitute the active ingredients:

[0353] Cholic acid 3g, mother of pearl (powder) 55g, hyodeoxycholic acid 4g, gardenia 30g, buffalo horn (powder) 20g, isatidis 190g, baicalin 6g, honeysuckle 80g.

[0354] Prescription of excipients:

[0355] Edetate disodium 4g, vitamin C sodium 15g, methylparaben 0.5g, propylparaben 2g.

[0356] Total production: 1000 bottles

[0357] Preparation:

[0358] a. Take the raw and auxiliary materials according to the prescription;

[0359]b. Add honeysuckle to 14 times the weight of honeysuckle, decoct twice, 1 hour each time, combine the decoction, filter, and when the filtrate is concentrated to 70°C, the relative density is 1.12-1.13, and ethanol is added to make the alcohol content reach 80 %, filter, adjust the pH value of the filtrate to 8.5, refrigerate, filter, recover the ethanol from the filtrate and concentrate it to 70°C, and the relative density is 1.14-1.15, add ethanol to make the alcohol co...

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Abstract

A Chinese medicine in the form of eyedrops is prepared proportionally from cholic acid, nacre, deoxychlolic acid of pig, capejasmine fruit, buffalo horn, isatis root, scutellaria root, honeysuckle flower, and auxiliary chosen from endrate disodium, VC sodium, tegosept M and propyl parasept.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a traditional Chinese medicine eye drop and a preparation process thereof. Background technique [0002] At present, there are many drugs used to treat external eye infections, mainly quinolones, aminoglycosides, hormones and nucleosides, such as ofloxacin, norfloxacin, ciprofloxacin, sulfacetamide, etc. Sodium, cortisone acetate, hydrocortisone, rifampicin, ribavirin, acyclovir, kanamycin, tobramycin, chloramphenicol, etc. These drugs are currently used clinically Extensive, definite curative effect, to a large extent alleviate the needs of patients with clinical medication, but at the same time there are many complex problems. Such as acute and chronic conjunctivitis caused by pathogenic microorganisms, the therapeutic effect of the above drugs is better, but for chronic conjunctivitis caused by non-pathogenic microorganisms and protracted and repeated condit...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P27/02A61K35/56A61K31/575A61K31/7048A61K35/32A61K35/618
Inventor 谢俊杨俊徐向阳蔡莹孙烨张惠田丽娟夏云万辉张庆晓
Owner JINLING PHARMA
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