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Pharmaceutical composition comprising notoginseng extract, Danshen extract and puerarin

A technology of composition and extract, applied in the field of medicine, to achieve the effect of small quality difference, less impurities and improved efficacy

Inactive Publication Date: 2011-01-12
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, there is no report on the medicine of treating cardiovascular and cerebrovascular diseases by utilizing the interaction of Panax notoginseng extract, Salvia miltiorrhiza extract and puerarin.

Method used

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  • Pharmaceutical composition comprising notoginseng extract, Danshen extract and puerarin

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1 10

[0029] Take the notoginseng medicinal material, crush it into a coarse powder, add ethanol to reflux extraction 3 times, each time for 3 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add water to an appropriate amount (each 1ml is equivalent to 2g of the original medicinal material), and refrigerate for 24 hours. Filtrate, add the filtrate to the treated weakly polar macroporous resin column, first elute with 2 times the column volume of water, then elute with 4 to 5 times of 80% ethanol, collect the eluate, and recover ethanol And vacuum drying, that is.

[0030] Experimental Example 2: Determination of the content of Panax notoginseng total saponins in Panax notoginseng extract

experiment example 2

[0031] Preparation of Reference Substance Solution Take 10 mg of the reference substance of Panax notoginseng saponins, vacuum-dry it at 60°C for 2 hours, weigh it accurately, put it in a 25ml measuring bottle, add methanol to dissolve and dilute to the mark, shake well, filter with dry filter paper, Precisely measure 5ml of the continued filtrate, put it in a 25ml measuring bottle, add methanol to dilute to the mark, shake well, and you get it.

[0032] Preparation of the test solution Take 15 mg of this product, accurately weigh it, put it in a 25ml measuring bottle, add methanol to dissolve and dilute to the mark, shake well, filter with dry filter paper, accurately measure 5ml of the subsequent filtrate, and put it in a 25ml measuring bottle In, add methanol to dilute to the mark, shake well, that is.

[0033] Determination method Precisely measure 1ml each of the test solution and the reference solution, put them in 10ml stoppered test tubes, evaporate to dryness, let coo...

experiment example 3

[0038] 1. Water extraction process screening test

[0039] The amount of water added, extraction time and extraction times had a great influence on the extraction results, so the content of total phenolic acids in salvia miltiorrhiza and the yield of the extract were taken as indicators, and the influence of the three factors on the extraction results was investigated by orthogonal test. The factors and level design are shown in Table 2.

[0040] Table 2 Alcoholic Extraction Process of Salvia Miltiorrhiza

[0041] level / factor

A water amount (times)

B Extraction time (hours)

C extraction times (times)

1

18

3

1

2

20

4

2

3

22

5

3

[0042] Test method Weigh 100g of Salvia miltiorrhiza, 9 parts in total, extract according to the requirements of each column number in Table 2, combine the extracts, filter, concentrate the filtrate and dilute to 500ml, and set aside.

[0043] Content De...

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Abstract

The invention belongs to the field of pharmacy, and discloses a medicinal composition containing pseudo-ginseng extract, red sage root extract and puerarin, which can be used for treating cardiovascular and cerebrovascular diseases, the invention also discloses the preparation containing the pharmaceutical composition and its preparing process, wherein the constituents include (by weight ratio) pseudo-ginseng extract 30-600 parts, red sage root extract 10-400 parts, and puerarin 50-1000 parts, The composition can be prepared into any clinically or pharmaceutically acceptable dose forms, preferably injections.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a medicinal composition containing notoginseng extract, salvia miltiorrhiza extract and puerarin, a preparation containing the medicinal composition and a preparation method thereof. [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer that threatens human health. According to relevant survey reports, there are more than 3 million people who die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total number of deaths in my country every year. 75% of people lost their ability to work to varying degrees, and 4% were seriously disabled. In particular, the age of its onset and death is increasingly younger, and how to effectively prevent and treat it has attracted people's attention. [0003] Cardiovascular and cerebrovascular diseases include coronary heart dise...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/10A61P9/12A61P3/06
Inventor 蔡军
Owner JIANGYIN TIANJIANG PHARMA
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