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Pre-metered dry powder inhaler for moisture-sensitive medicaments

A dry powder inhaler, a predetermined amount of technology, used in inhalers, medical containers, drug combinations, etc.

Active Publication Date: 2011-05-25
BOEHRINGER INGELHEIM INT GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such prior art inhalers open the powder dose before the inhaler is ready for inhalation, thus exposing this dose to the surrounding environment and possibly moist air exhaled by the user

Method used

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  • Pre-metered dry powder inhaler for moisture-sensitive medicaments
  • Pre-metered dry powder inhaler for moisture-sensitive medicaments
  • Pre-metered dry powder inhaler for moisture-sensitive medicaments

Examples

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Embodiment Construction

[0028] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0029] The present invention relates to DPI loaded with a moisture sensitive drug, preferably comprising tiotropium, and describes dose release to achieve high levels of released FPD. Preferably, the DPI is a predetermined amount. Additionally, the present invention addresses how such sensitive drugs can be protected from the moment of dose formation and sealing to the moment the user inhales the selected dose, throughout all stages of storage, transport, distribution, restorage and final administration. No moisture problem. Suitable dry powder inhalers for moisture sensitive medicaments are also disclosed.

[0030] The present invention discloses a dry, moisture-proof, ready-to-load and seal container containing a dose of tiotropium in a high FPD formulation containing at least one excipient. The term "tiotropium" is a generic term for all active forms thereof, including pharmaceutically acceptable salts (especially...

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Abstract

The invention is directed to a pre-metered dry powder inhaler provided with a dry powder dose of tiotropium and excipient(s) loaded into a container comprising a dry, high barrier seal, which prevents ingress of moisture so that the fine particle structure of the powder dose is preserved. The dry powder dose has been formed by either volumetric or electric field dose forming methods. The invention is also directed to a dry powder dose of tiotropium loaded into a container as described above. The dry powder inhaler and the dry powder dose of the invention is intended for use in the treatment of asthma and other respiratory disorders.

Description

field of invention [0001] The present invention relates to dry powder inhalers (DPIs) that deliver high and stable doses of fine particles. The inhaler uses a highly leak-proof sealed container containing at least one metered dose of a formulation comprising at least one excipient and tiotropium drug. [0002] Additional advantages and other features of the invention will be set forth in part in the ensuing description, and will be apparent to those of ordinary skill in the art by examination of the following contents, or can be learned by practice of the invention. The advantages of the invention may be realized and attained as particularly pointed out in the appended claims. As will be realized, the invention is capable of other and different embodiments, and its several specific embodiments are capable of modifications in various obvious respects, all without departing from the invention. This description is considered to be illustrative in nature, not restrictive. Back...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K9/72A61M15/00A61J1/00A61K31/46A61P11/06A61P11/08A61K9/00A61K31/4745
CPCA61K31/4745A61K9/0075A61K9/008A61K31/439A61P11/00A61P11/06A61P11/08A61K31/4748A61J1/00
Inventor M·迈尔曼S·卡兰德A·尼米
Owner BOEHRINGER INGELHEIM INT GMBH
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