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Water-based magnetic liquid of surface group rich, high stability and its preparation method

A high-stability, magnetic liquid technology, applied in the direction of magnetic liquid, inductor/transformer/magnet manufacturing, electrical components, etc., can solve the problems of less surface active groups, small surface polymer adsorption, drug loading limit, etc. Achieve the effect of good stability and dispersion, rich active groups, and increased drug loading

Inactive Publication Date: 2007-02-14
GUANGZHOU INST OF ENERGY CONVERSION - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Nano-magnetic particles with linear polymers as stabilizers have some insurmountable shortcomings as drug carriers, including: 1) The adsorption amount of surface polymers is small, the surface active groups are correspondingly less, and the drug loading capacity is limited
2) The molecular weight and distribution range of linear polymers are not easy to control, resulting in insufficient stability and repeatability of the drug loading and drug release characteristics of the preparation

Method used

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  • Water-based magnetic liquid of surface group rich, high stability and its preparation method

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Experimental program
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Effect test

Embodiment 1

[0022] 1. the freshly synthesized ferric ferric oxide nano-magnetic particles with a diameter of about 10nm are repeatedly washed with distilled water (the preparation method of the said nano-magnetic ferric ferric oxide particles has been disclosed, referring to Chinese invention patent ZL01107440.X), so that the concentration The conductivity of the 0.5g / 100ml nano-iron ferric oxide colloid solution is reduced to less than 100 μs / cm, and then ultrasonically dispersed for 2 minutes to obtain a nano-ferric oxide sol.

[0023] 2. In the nanometer ferric oxide colloidal solution whose concentration is 0.5g / 100m1, the molar ratio of dendritic polymer and nanometer ferric oxide particle is 45: 1 to add Dendritech, Inc. The company's degree of polymerization is the end of 6 Amino-based polyamidoamine dendrimer aqueous solution, adjust the pH value of the system to 8, continue to stir for 30 minutes, and react in a water bath at 50°C; , reducing the conductivity of the reaction syst...

Embodiment 2

[0025] Step 1. is the same as embodiment 1, and difference is that in step 2. the mol ratio by dendrimers and nano iron ferric oxide particles is 45: 1 to add Dendritech, and the degree of polymerization of Inc. company is 6.5, comprises the polymer of terminal carboxyl group For an aqueous solution of amidoamine dendrimer, adjust the pH value of the reaction system to 4.5-5, and the rest of the steps are the same as in Example 1 to prepare a water-based magnetic liquid with dendrimer as a stabilizer. The adsorption capacity of the polymer on the surface of the nano-Fe3O4 particles is about 0.6g / g Fe 3 o 4 , the drug loading amount of cisplatin reaches about 800 mol / mol particles, and the particles can remain stable in the range of pH5.5-10.

Embodiment 3

[0027] Step 1. is the same as Example 1, and the difference is that in step 2. the mol ratio of dendrimers and nano iron ferric oxide particles is 90: 1 to add Dendritech, Inc.'s degree of polymerization is 2.5, comprising terminal carboxyl polymers For an aqueous solution of amidoamine dendrimer, adjust the pH value of the reaction system to 4.5-5, and the rest of the steps are the same as in Example 1 to prepare a water-based magnetic liquid with dendrimer as a stabilizer. The adsorption amount of the polymer on the surface of the nano-ferric oxide particles is about 0.2g / g Fe 3 o 4 , the drug loading amount of cisplatin reaches about 300 mol / mol particles, and the particles can remain stable in the range of pH5.5-10.

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Abstract

This invention provides a stabilized water-base magnetic solution and its preparation method in rich surface active group with controllable number, in which, the solution includes: nano-magnetic Fe3O4 particles, stabilizer and water applying polyamide-base amine branch like polymer as the stabilizer, the polymer and modified nano-magnetic Fe3O4 particles are scattered in water forming a stable collide solution. The preparation method includes: 1, confecting nano-Fe3O4 sol, 2, surface-modifying the Fe3O4 particles and scattering them in water.

Description

technical field [0001] The invention relates to a water-based magnetic liquid, in particular to a water-based magnetic liquid with abundant surface groups and high stability and a preparation method thereof. technical background [0002] The so-called water-based magnetic liquid refers to a stable colloidal system formed by highly dispersed nano-magnetic particles adsorbed with stabilizers in water, mainly composed of nano-magnetic particles, stabilizers and water. Water-based magnetic liquids can be widely used in biomedical fields such as magnetically targeted drug delivery systems and intracellular magnetic liquid hyperthermia. The current water-based magnetic liquid can be divided into three categories according to the type of stabilizer used: 1. Use water-soluble small organic molecules such as amino acids, citric acid, folic acid, etc. as chelating agents and stabilizers; 2. Use surface Active agents form a double-layer adsorption mode on the surface of nano-magnetic ...

Claims

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Application Information

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IPC IPC(8): H01F1/44H01F41/00
Inventor 徐雪青徐刚
Owner GUANGZHOU INST OF ENERGY CONVERSION - CHINESE ACAD OF SCI
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