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Injectio for nanometer notoginsenoside and its preparing method

A technology of aescin and injection preparations, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., and can solve the problems of unretrieved nano-aescin injection preparations, etc.

Inactive Publication Date: 2007-02-07
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After reviewing the literature and patents, no information on nano-aescin injection preparations was found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] (1) Extraction of effective parts of aescin:

[0115] Take 503 grams of sala seeds, crush them, put them into an ultrasonic extraction tank, control the extraction temperature at 25°C, extract twice, 5 minutes each time, and reserve the residue, combine the extracts, concentrate in a rotary scraping device, and control the concentration temperature at 40°C , the vacuum degree is 0.1 atmosphere, and the relative density is 1.15 when concentrated to 40 ° C. The concentrated solution is left at 0 ° C for 24 hours to remove the grease layer on the surface of the concentrated solution, and the concentrated solution from which the grease layer is removed is combined with the residue. Water and ethanol, so that the alcohol content is 50%, put it into an ultrasonic extraction tank, control the temperature at 25°C, extract twice, 15 minutes each time, combine the extracts, concentrate the ethanol in a rotary wiper to the end, and control the concentration temperature 40 ℃, the v...

Embodiment 2

[0124] (1) Extraction of effective parts of aescin:

[0125] Take 632 grams of sala seeds, crush them, put them into an ultrasonic extraction tank, control the extraction temperature at 50°C, extract 4 times, each time for 15 minutes, and reserve the residue, combine the extracts, concentrate in a rotary scraper, and control the concentration temperature at 50°C , the vacuum degree is 0.2 atmospheres, and the relative density is 1.25 when it is concentrated to 50 ° C. The concentrated solution is left at 4 ° C for 48 hours to remove the grease layer on the surface of the concentrated solution, and the concentrated solution from which the grease layer is removed is combined with the residue. Water and ethanol, so that the alcohol content is 70%, put it into an ultrasonic extraction tank, control the temperature at 50°C, extract 4 times, each time for 45 minutes, combine the extracts, concentrate the ethanol in a rotary scraper to the end, and control the concentration temperatur...

Embodiment 3

[0134] (1) Extraction of effective parts of aescin:

[0135] Take 571 grams of Sala seeds, crush them, put them into an ultrasonic extraction tank, control the extraction temperature at 40°C, extract 3 times, each time for 10 minutes, and reserve the residue, combine the extracts, concentrate in a rotary scraping device, and control the concentration temperature at 45°C , the vacuum degree is 0.15 atmospheres, and the relative density is 1.20 when it is concentrated to 45 ° C. The concentrated solution is left at 2 ° C for 36 hours to remove the grease layer on the surface of the concentrated solution, and the concentrated solution from which the grease layer is removed is combined with the residue. Water and ethanol, so that the alcohol content is 60%, put it into an ultrasonic extraction tank, control the temperature at 40°C, extract 3 times, each time for 30 minutes, combine the extracts, concentrate the ethanol in a rotary scraper to the end, and control the concentration t...

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Abstract

The invention discloses a nanometer aescin injection and preparing method, which is characterized by the following: extracting from effective position from aescin to prepare nanometer aescin with medical carrier; blending with drug auxiliary material to prepare water injection, transfusion agent and powder injection; controlling the content of beta-aescin at 50-85%.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a nano-aescin injection preparation and a preparation method thereof. Background technique [0002] Salazi is the fruit or seed of Aesculus Aesculus, Aesculus aesculus, Chinese chestnut, and its ineffective components are fatty oil, starch, fiber, etc. The fatty oil is mainly glycerin of oleic acid and stearic acid Ester; its active ingredient is aescin, which belongs to triterpenoid saponin compound. It has anti-inflammatory, anti-exudation, restores capillary permeability, improves venous tension, improves blood circulation, expands arteries, expands coronary arteries, increases resistance Hypoxic ability, promoting the recovery of brain function, etc., the clinical application is mainly its sodium salt, that is, sodium aescinate for injection, but in clinical application, there are a large number of serious adverse reactions: 1. Cause ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K36/185A61K9/14A61K9/08A61K9/19A61P29/00A61P9/10
Inventor 张晴龙
Owner 张晴龙
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