Methods and compositions using thalidomide for the treatment and management of cancers and other diseases

A thalidomide and cancer technology, applied in the field of pharmaceutical compositions and drug regimens, can solve problems such as unclear properties

Inactive Publication Date: 2007-01-24
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Even though there is a general mechanism by which thalidomide helps treat some cancers, its nature is unclear

Method used

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  • Methods and compositions using thalidomide for the treatment and management of cancers and other diseases

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Embodiment Construction

[0025] A first embodiment of the present invention includes a method of treating, controlling or preventing cancer comprising administering a therapeutically or prophylactically effective amount of thalidomide or a pharmaceutically acceptable salt thereof to a patient in need of such treatment or prevention , solvate, hydrate, stereoisomer, clathrate or prodrug.

[0026] In particular methods encompassed by this embodiment, thalidomide is used in combination with other drugs ("second active agents") or methods for the treatment, management and prevention of cancer. Secondary active agents include small and large molecules such as proteins and antibodies, examples of which are provided herein, and stem cells. Methods or treatments that may be used in combination with thalidomide include, but are not limited to, surgery, blood transfusion, immunotherapy, biological therapy, radiation therapy, and other non-drug therapies currently used to treat, prevent, or manage cancer.

[00...

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Abstract

Methods of treating, preventing and / or managing cancer and diseases and conditions associated with or characterized by unwanted angiogenesis are disclosed. Particular methods include administration of thalidomide alone or in combination with a second active ingredient. The invention also relates to a method of reducing or avoiding adverse side effects associated with chemotherapy, radiotherapy, hormone therapy, biological therapy or immunotherapy comprising administering thalidomide. Pharmaceutical compositions, single unit dosage forms and kits suitable for use in the methods of the invention are also disclosed.

Description

1. Field of invention [0001] The present invention relates to methods of treating, preventing and / or managing certain cancers and other diseases, including but not limited to those associated with unwanted angiogenesis or This is the characteristic disease. In particular, the invention includes the use of specific combinations or "cocktails" of drugs or other therapies, such as radiation therapy, to treat these specific cancers, including those that do not respond to conventional therapies. The invention also relates to pharmaceutical compositions and regimens. 2. Background of the invention [0002] 2.1 Pathology of cancer and other diseases [0003] The main features of cancer are an increase in the number of abnormal cells derived from a normal tissue, the invasion of adjacent tissues by these abnormal cells, or the spread of malignant cells to local lymph nodes and distant sites through the lymph or blood (metastasis). Clinical data and molecular biology studies confi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61K
CPCA61K31/00A61K31/454A61K45/06A61P1/02A61P1/04A61P1/16A61P11/00A61P11/06A61P13/08A61P15/00A61P17/00A61P17/02A61P17/06A61P19/00A61P19/02A61P19/10A61P25/00A61P25/22A61P27/02A61P27/06A61P27/10A61P27/16A61P29/00A61P3/14A61P31/04A61P31/08A61P31/10A61P31/12A61P31/14A61P31/22A61P33/02A61P33/06A61P35/00A61P35/02A61P35/04A61P37/04A61P37/08A61P39/02A61P7/00A61P7/06A61P9/00A61P9/04A61P9/08A61P9/10A61K2300/00
Inventor 杰罗米·B·杰奥迪斯
Owner CELGENE CORP
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