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Preparing process for Chinese medicine for treating vocal nodules and polyp of vocal cord and its use

A technology for vocal cord polyps and vocal cord nodules, which is applied in the preparation process of traditional Chinese medicine for symptoms of vocal cord polyps and the field of treatment of vocal cord nodules, can solve the problems of excessive loss, labor-intensive, time-consuming, etc., achieve tissue proliferation inhibition, reduce whole blood viscosity, and improve utilization Effect

Active Publication Date: 2007-01-24
XIAN BEILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] CN1544077A discloses a kind of " Chinese medicine for the treatment of chronic and dull throat symptoms ", and its tablet, capsule preparation process loses more in the process of raw material concentration, and the concentrated extract density is unfavorable for mixing, is not easy to dry, takes a lot of work, Time-consuming, and the utilization rate of raw materials and the extraction rate of active ingredients are not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0011] Experimental Example 1 Water Extraction Process Optimization

[0012] According to the analysis of the influencing factors of the water extraction process, the amount of water added, the decoction time, and the number of decoctions were selected as the main factors. Using the orthogonal test method, the amount of dry paste and the transfer rate of chlorogenic acid were used as indicators to screen out the best. process conditions.

[0013] 1. Investigation on the water absorption of medicinal materials:

[0014] According to the above-mentioned prescription proportions, a total of 149.3 g of the medicinal materials extracted by water was weighed, soaked in 10 times the amount of water until thoroughly filtered, and the average water absorption rate was measured to be 208%.

[0015] 2. Orthogonal experimental design

[0016] After analyzing and comparing the extraction times, extraction time, water addition and other factors involved in the extraction process, three le...

experiment example 2

[0035] Experimental Example 2 Alcohol precipitation process optimization

[0036] 1. Screening of alcohol precipitation conditions

[0037] The water extract of medicinal materials, because the extract is easy to absorb moisture and has large impurities, it should be treated with alcohol during the preparation process to retain the active ingredients, remove impurities, and reduce the dosage. Therefore, for different concentrations of alcohol precipitation The total ointment output and chlorogenic acid content were investigated. The water decoction with starch and mucilage is purified by alcohol precipitation. After analyzing the influencing factors of alcohol precipitation, select the concentration of alcohol precipitation (A), the relative density of liquid medicine (B), and the standing time (C), and design an orthogonal experiment according to L9(3)4. The acid transfer rate was used as an evaluation index for comprehensive analysis. See Table 5 for the level table of de...

experiment example 3

[0046] Experimental Example 3 Water Extraction and Alcohol Precipitation Process and Optimization of Water Extraction Process

[0047] According to the parameters determined by the above-mentioned water extraction process and water extraction and alcohol precipitation process, the pilot production was carried out according to 10 times the amount of the prescription, and the shaped particles were investigated to compare the similarities and differences of the two processes.

[0048]1. Comparison of test results of three batches of pilot products

[0049] The test results of the three batches of pilot products are shown in Table 8.

[0050] batch number

A01

A02

A03

B01

B02

B03

Feeding amount of powdered medicinal materials (kg)

Amount of fine powder (kg)

Powder yield (%)

Puffball powder amount (g)

Medicinal material extraction dosage (Kg)

Amount of extract extracted from water (Kg)

Amount of alcoho...

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Abstract

The present invention relates to Chinese medicine preparation, and is especially the preparation process and application of Chinese medicine preparation for treating vocal nodules and polyp of vocal cord. The preparation process of the present invention is stable, practical, high material utilizing rate and high effective component extracting rate, and the Chinese medicine preparation has high chlorogenic acid content. The Chinese medicine preparation has the functions of promoting blood circulation to disperse blood clots, lowering blood viscosity, lowering fibrinogen content and platelet adhesiveness, and inhibiting proliferation of granulation tissue.

Description

Technical field: [0001] The invention relates to a preparation process and application of a traditional Chinese medicine preparation, in particular to a preparation process and application of a traditional Chinese medicine for treating symptoms of vocal nodules and vocal cord polyps. Background technique: [0002] Throat disease is a common clinical disease and frequently-occurring disease, and the incidence rate has been increasing nationwide in recent years. At present, the number of patients with throat disease in my country is increasing. About 12% of the total number of patients, the high incidence rate will cause the attention of the medical circle and the people of the country. [0003] At present, there are not many pure Chinese medicine preparations for treating throat diseases in China, especially pure Chinese medicine varieties such as treating chronic laryngitis (vocal cord nodules, vocal cord polyps, and vocal cord mucosal thickening) are...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P11/04A61K35/38A61K35/56A61K35/57A61K35/64
Inventor 黄小华付彬
Owner XIAN BEILIN PHARMA
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