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Medicinal composition containing sulfourea antidiabetic medicine and vitamine B

A technology of B vitamins, anti-diabetes, applied in the field of pharmacy

Inactive Publication Date: 2007-01-17
深圳市奥萨药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] The few existing studies focus on the relationship between biguanides (especially metformin) and homocysteine, and thus deduce that the combination of metformin and B vitamins (especially folic acid) can lower blood sugar or in The beneficial effect of lowering blood sugar based on improving the level of homocysteine, however, there is no effective drug on the market at present, which can not only effectively treat the abnormal state of blood sugar in diabetic patients, but also have a good effect on preventing diabetic complications. Beneficial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1 Preparation of Compound Glibenclamide Folic Acid Tablets (1000 Tablets)

[0072] Formula: Glibenclamide 5g

[0073] Folic acid 0.8g

[0074] Microcrystalline Cellulose 50g

[0075] Sodium carboxymethyl starch 20g

[0076] Low-substituted hydroxypropyl cellulose 20g

[0077] Povidone 95% ethanol solution appropriate amount

[0078] Magnesium Stearate 1%

[0079] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry for later use. Take 0.8g of folic acid and 5g of glibenclamide and mix uniformly according to the method of equal increase, add 50g of microcrystalline cellulose and 10g of sodium carboxymethyl starch, mix uniformly according to the method of equal increase, and use 5% povidone 95% ethanol solution Make soft material, granulate with 20 mesh sieve, dry at 40°C for about 2 hours, granulate with 20 mesh sieve, control the water content of the granules to 2-3%, mix the drie...

Embodiment 3

[0088] Example 3 Preparation of Compound Gliclazide Vitamin B12 Tablets (1000 Tablets)

[0089] Recipe: Gliclazide 50g

[0090] Vitamin B12 2g

[0091] Microcrystalline Cellulose 50g

[0092] Sodium carboxymethyl starch 20g

[0093] Low-substituted hydroxypropyl cellulose 20g

[0094] Povidone 95% ethanol solution appropriate amount

[0095] Magnesium Stearate 1%

[0096] The preparation method was the same as in Example 1, and each tablet contained 50 mg of gliclazide and 2 mg of vitamin B12 in the prepared compound tablet, with a mass ratio of 25:1.

Embodiment 4

[0097] Example 4 Preparation of Compound Gliclazide Folic Acid Tablets (1000 Tablets)

[0098] Recipe: Gliclazide 50g

[0099] Folic acid 0.8g

[0100] Microcrystalline Cellulose 50g

[0101] Sodium carboxymethyl starch 20g

[0102] Low-substituted hydroxypropyl cellulose 20g

[0103] Povidone 95% ethanol solution appropriate amount

[0104] Magnesium Stearate 1%

[0105] The preparation method was the same as in Example 1, and each tablet contained 50 mg of gliclazide and 0.8 mg of folic acid in the prepared compound tablet, with a mass ratio of 50:0.8.

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PUM

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Abstract

A composite medicine for treating diabetes and preventing its complication contains antidiabetic sulfonylurea medicine or its metabolite or its salt, one or more vitamins in family B, and medicinal carrier.

Description

technical field [0001] The present invention relates to a pharmaceutical combination containing a medicinal dosage of sulfonylurea antidiabetic drugs, one of its active metabolites or their salts, a medicinal dosage of one or more of B vitamins and a pharmaceutically acceptable carrier and the use of the composition in the preparation of medicaments for treating diabetes. The present invention belongs to the field of pharmacy. Background technique [0002] Diabetes mellitus is a metabolic disease of multiple etiologies characterized by chronic hyperglycemia accompanied by disturbances in carbohydrate, fat and protein metabolism due to defects in insulin secretion and / or action. On October 12, 2004, the Ministry of Health, the Ministry of Science and Technology and the National Bureau of Statistics published the report "Chinese Residents' Nutrition and Health Status", which pointed out that the prevalence of diabetes among residents aged 18 and over in my country was 2.6%, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/714A61K31/17A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61K9/70A61P3/10
Inventor 于多陈明侠李华戴成祥王燕王文艳邢厚恂陈光亮徐希平
Owner 深圳市奥萨药业有限公司
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