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Method for preparing freeze-dried powder of Danhong injection for treating cardiovascular, cerebrovascular diseases, and test method

A technology for cardiovascular and cerebrovascular diseases and injections, which is applied in the field of preparation of Danhong freeze-dried powder for injections, and can solve the problems that most impurities cannot be removed, the quality of the preparation is low, and it is not conducive to transportation and storage.

Inactive Publication Date: 2006-12-06
HAINAN GENERAL & KANGLI PHARMA
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Problems solved by technology

Since the injection uses the water-soluble part, and there is no purification process in the preparation method in the original quality standard, most of the impurities cannot be removed, the product quality control is difficult, the preparation quality is low, and the stability of the original dosage injection is poor. Good for transportation and storage

Method used

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  • Method for preparing freeze-dried powder of Danhong injection for treating cardiovascular, cerebrovascular diseases, and test method

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Embodiment Construction

[0070] A preparation method of Danhong freeze-dried powder for injection for treating cardiovascular and cerebrovascular diseases, comprising

[0071] The medicinal materials of Salvia miltiorrhiza and safflower were extracted separately, and prepared by water extraction and alcohol precipitation method to prepare Danhong stock solution for injection and Danhong freeze-dried powder for injection:

[0072] 1. Add 15kg of Salvia miltiorrhiza to 8 times the amount of water, decoct three times, 1.5 hours each time, combine the decoction, and filter;

[0073] 2. Add 20 times the amount of water to 5kg safflower, soak twice at 80°C for 1 hour each time, and filter;

[0074] 3. Combine the above filtrates, concentrate under reduced pressure to a clear paste with a relative density of 1.15 (60°C), add ethanol to make the alcohol content reach 70%, refrigerate for 24 hours, filter, reclaim ethanol from the filtrate, and concentrate to a relative density of 1.20 ( 60°C), then add ethan...

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Abstract

A freeze-dried powder injection for treating cardiovascular and cerebrovascular diseases is prepared from red sage root and safflower through immersing safflower in worm water, decocting red sage root, mixing the immersing water with decoction, concentrating, depositing in alcohol, examining and freeze drying. Its test method is to measure the contents of danshinolic acid, danshensu sodium, protocatechuic aldehyde, and safflor yellow.

Description

[technical field] [0001] The invention relates to the technical field of preparation technology of traditional Chinese medicine, in particular to the preparation technology of Danhong freeze-dried powder for injection [Background technique] [0002] Danhong injection is composed of salvia miltiorrhiza and safflower. According to modern pharmacological analysis, salvia miltiorrhiza contains tanshinone, salvia phenol, vitamin E and other substances. Safflower is the dried flower of Compositae safflower. It is a traditional Chinese medicine in my country. Its nature and flavor are pungent and warm, and it also enters the heart meridian. It can expand coronary arteries, increase coronary blood flow, and reduce myocardial oxygen consumption. It is widely used in modern medicine. For the treatment of diseases of the cardiovascular system. The formula is scientific and reasonable, and conforms to the theory of traditional Chinese medicine, and the combined use of the two medicines ...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/19A61P9/10G01N30/02G01N33/15
Inventor 汤旭东朱正兵
Owner HAINAN GENERAL & KANGLI PHARMA
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