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Method for making artificial breast wall and artificial bone

A technology of artificial bone and chest wall, which is applied in the field of preparation of medical artificial bone materials, and achieves the effect of good biocompatibility

Inactive Publication Date: 2006-10-25
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The technical problem to be solved by the present invention is to provide a preparation method of artificial chest wall and artificial bone material to make up for the deficiencies or defects of the prior art and meet the needs of medicine and specific groups of people

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) The dry-wet-spun L-lactic acid long fibers with a viscosity of IV=2.75 and chitosan long fibers with a molecular weight of 100,000 are blended in a ratio of 1:1, and woven into a two-dimensional fiber fabric with 350um holes;

[0028] (2) Blending slices of L-polylactic acid with IV=6.75 and polycaprolactone with IV=2.50 in a ratio of 1:0.75, then adding chitosan long fibers in a weight ratio of 1:0.005 with polylactic acid slices;

[0029] (3) Put the blended substance obtained in step (2) into a mold with a length of 10cm, a width of 5cm, and a depth of 4cm; the mold is placed in a high-pressure tablet press, and pressed at 180°C under 6 atmospheres to form plate;

[0030] (4) Wrap the plate described in step (3) according to the required size with the fabric prepared in step (1), and obtain a "sandwich" artificial chest wall and artificial bone material.

Embodiment 2

[0032] (1) The dry-wet-spun L-lactic acid long fibers with a viscosity of IV=1.5 and the chitosan long fibers with a molecular weight of 150,000 are blended in a ratio of 1:1.5, and woven into a two-dimensional fiber fabric with 100um holes;

[0033] (2) Blending slices of L-polylactic acid with IV=1.75 and polycaprolactone with IV=1.5 in a ratio of 1:0.05, then adding chitosan long fibers in a weight ratio of 1:0.25 with polylactic acid slices;

[0034] (3) Put the blended substance obtained in step (2) into a mold with a length of 10cm, a width of 5cm, and a depth of 4cm; the mold is placed in a high-pressure tablet press, and pressed at 70°C and 9 atmospheres to form plate;

[0035] (4) The fabric prepared in step (1) wraps the plate described in step (3) according to the required size to obtain a "sandwich" artificial chest wall and artificial bone material.

Embodiment 3

[0037] (1) Blend dry-wet-spun L-lactic acid long fibers with a viscosity of IV=2 and chitosan long fibers with a molecular weight of 50,000 at a ratio of 1:0.1, and weave a two-dimensional fiber fabric with 200um pores ;

[0038] (2) Blending slices of L-polylactic acid with IV=8.75 and polycaprolactone with IV=2 in a ratio of 1:1.25, then adding chitosan long fibers in a weight ratio of 1:0.001 with polylactic acid slices;

[0039] (3) Put the blended substance obtained in step (2) into a mold with a length of 10cm, a width of 5cm, and a depth of 4cm; the mold is placed in a high-pressure tablet press, and pressed at 200°C under 3 atmospheres to form plate;

[0040] (4) Wrap the plate described in step (3) according to the required size with the fabric prepared in step (1), and obtain a "sandwich" artificial chest wall and artificial bone material.

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PUM

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Abstract

The present invention relates to a preparation method of artificial thoracic wall and artificial bone material. Said method includes the following steps: mixing polylactic acid fibre and chitosan fibre, weaving them into fabric with 100 um-350 um holes; mixing polylactic acid chips and polycaprolactone chips according to weight ratio of 1:0.05-1.25, then mixing them with chitosan fibre and pressing them to obtain plate material; wrapping said plate material with the above-mentioned obtained fabric, and adopting sewing mode to make three layers be connected together. Said material can be used for repairing thoracic wall with large-area deficiency and forming new bone.

Description

technical field [0001] The present invention relates to a preparation method of medical artificial bone material, in particular to a "sandwich" type artificial chest wall and artificial bone material composed of degradable fiber fabric and plate and its preparation method Background technique [0002] Artificial chest wall According to reports, there are many kinds of materials to prepare. Human body's own tissue and allogeneic tissue, including the use of myocutaneous flap, periosteum flap, autologous fascia lata, diaphragm, ribs, etc. Metal materials include metal mesh, metal plate, metal strip and metal rod made of tantalum sheet, titanium sheet, titanium alloy, stainless steel, etc. Inorganic materials and ceramic materials, for example, bioceramics, bioglass, calcium phosphate, bone cement, hydroxyapatite, etc. Synthetic materials, in which polypropylene and polyester are currently the main fiber-wrapped bone cement "sandwich" materials, are clinically used and more s...

Claims

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Application Information

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IPC IPC(8): A61L27/14
Inventor 张秀芳程正迪
Owner DONGHUA UNIV
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