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Process for preparing carboxymethyl chitosan calcium and application thereof

A carboxymethyl chitosan calcium, technology of carboxymethyl chitosan, applied in the preparation and application field of carboxymethyl chitosan calcium

Inactive Publication Date: 2006-10-11
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the preparation method of carboxymethyl chitosan calcium and the application of carboxymethyl chitosan calcium have not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of carboxymethyl chitosan calcium

[0012] Weigh 10 g of carboxymethyl chitosan powdery solid, put it in a clean beaker, add 500 ml of deionized water, stir and dissolve at room temperature, and obtain carboxymethyl chitosan aqueous solution. Weigh 3 g of anhydrous calcium chloride, put it in a beaker, add 30 ml of deionized water, stir and dissolve to obtain an aqueous solution of calcium chloride. Slowly pour the anhydrous calcium chloride aqueous solution into the carboxymethyl chitosan aqueous solution under stirring, continue stirring at room temperature for 0.5 hour, and filter to obtain a filtrate. The filtrate was placed in a 200ml beaker, 100ml of deionized water was added, stirred and washed for 20 minutes, filtered to obtain a filtrate, and this process was repeated 3 times in total. The obtained filtrate is dehydrated with 95% ethanol aqueous solution, filtered, and dried at 60-70° C. to obtain carboxymethyl chitosan calcium. ...

Embodiment 2

[0013] Embodiment 2: the preparation of carboxymethyl chitosan calcium

[0014] Weigh 10 g of carboxymethyl chitosan powdery solid, put it in a clean beaker, add 1000 ml of deionized water, stir and dissolve at room temperature to obtain carboxymethyl chitosan aqueous solution. Weigh 4g of anhydrous calcium chloride, put it in a clean mortar, and grind it into a fine powder. Slowly pour the anhydrous calcium chloride powdery solid into the carboxymethyl chitosan aqueous solution under stirring, continue stirring for 0.5 hour at room temperature, and centrifuge to obtain a precipitate. Place the precipitate in a 200ml beaker, add 100ml deionized water, stir and wash for 20 minutes, filter to obtain a filtrate, repeat this process a total of 3 times. The obtained filtrate is dehydrated with 95% ethanol aqueous solution, filtered to obtain the filtrate, and the latter is dried at 60-70° C. to obtain carboxymethyl chitosan calcium.

[0015] The carboxymethyl chitosan used in Exa...

Embodiment 3

[0017] Embodiment 3: Carboxymethyl chitosan calcium is to the hemostatic test of rat

[0018] Wistar rats were used as experimental animals, 20 rats, both male and female, weighing 250g±20g. The test was divided into two groups: cotton gauze control group and carboxymethyl chitosan calcium test group, 10 rats in each group. The rats were anesthetized by intraperitoneal injection of 2% pentobarbital sodium at 30 mg / Kg body weight respectively, and the rats were fixed on the operating rack with the abdomen facing up. A 1.5 cm long and 2 mm deep incision was made on the abdominal hair removal site with a sterilized blade, and blood flowed out. The rats in the cotton gauze control group were bandaged with sterile double-layer gauze along the incision; the carboxymethyl chitosan calcium test group sprinkled about 2 mm thick carboxymethyl chitosan calcium powder on the incision of the rats after autoclaving at 121 °C (prepared by the method of Example 2). During the operation, th...

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PUM

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Abstract

This invention is the preparation method of carboxymethyl chitosan calcium. The procedure is as followings: dissolve carboxymethyl chitosan calcium in water, react with the aqueous solution or powder of one among calcium chloride, calcium acetate, calcium gluconate and calcium lactate, filer, centrifuge, wash the solid product, dessicate and dry. The carboxymethyl chitosan calcium's molecular weight is in the range of 1KD-1000KD. Weitht ratio in the reaction between carboxymethyl chitosan calcium and chitosan calcium (the others is the same) is 10:0.1-6. The carboxymethyl chitosan calcium we get here could be used wound or operational haemostasis. It also helps supplement calcium and get rid of the deleterious element lead. In the conclusion, our product carboxymethyl chitosan calcium could be used as haemostatic, replenishing calcium regent and anti-lead reagent.

Description

technical field [0001] The present invention relates to a preparation method of carboxymethyl chitosan calcium, and the application of carboxymethyl chitosan calcium, especially its application in trauma or operation hemostasis, in supplementing calcium element in the body, and in excreting harmful calcium in the body. element lead. Background technique [0002] Calcium is an indispensable constant element in the human body, and plays an important role in various physiological activities of the body, such as maintaining the normal permeability of blood vessels, controlling inflammation and edema; inhibiting the excitability and nerve impulse of neuromuscular muscles; facilitating myocardial contraction, Maintain the heartbeat rhythm; participate in the blood coagulation process, participate in the regulation of enzyme activity in the body, maintain bone health, etc. [0003] At present, there are many kinds of calcium preparations on the domestic market, mainly divided into...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K31/722A61P3/00
Inventor 韩宝芹刘万顺蔡文娣
Owner OCEAN UNIV OF CHINA
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