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Method for extracting alpha- glucosidase inhibitor from traditional Chinese cinnamomum cassia

A technology of glucosidase and inhibitor, which is applied in the fields of Chinese herbal medicine preparation and chemical and chemical industry, and achieves the effects of simple process, convenient operation and no environmental pollution

Inactive Publication Date: 2006-10-04
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, it has been found that cinnamon also has the effect of preventing diabetes, but there is no report on the study of extracting α-glucosidase inhibitors from cinnamon and conducting research on the hypoglycemic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The process and steps of α-glucosidase inhibitor extraction in the present embodiment are as follows:

[0014] (1) First, 300g of raw material Chinese medicine cinnamon is pulverized, and sieved to pass through an 80-mesh sieve; then the powder is put into supercritical CO 2 Extraction in the extraction kettle of the fluid extraction device, supercritical CO 2 The fluid flows into the extraction kettle at a flow rate of 25kg per hour, the pressure in the extraction kettle is maintained at 25MPa, and the temperature is maintained at 40°C;

[0015] (2) CO 2 The fluid enters the separation tank I and the separation tank II; the pressure of the separation tank I is 6MPa, and the temperature is 55°C; the pressure of the separation tank II is 6MPa, and the temperature is 35°C; under the above conditions, supercritical CO 2 Fluid extraction for 2 hours, finally the material left in the separation tank I and the separation tank II is a component without inhibitory activity, a...

Embodiment 2

[0018] The extraction process and steps of this embodiment are exactly the same as those of Embodiment 1 above. The steps are as follows:

[0019] (1) First, 300g of raw material Chinese medicine cinnamon is pulverized, and sieved to pass through a 60-mesh sieve; then the powder is put into supercritical CO 2 Extraction in the extraction kettle of the fluid extraction device, supercritical CO 2 The fluid flows into the extraction kettle at a flow rate of 30kg per hour, the pressure in the extraction kettle is maintained at 30MPa, and the temperature is maintained at 45°C;

[0020] (2) CO 2 The fluid enters the separation tank I and the separation tank II; the pressure of the separation tank I is 8MPa, and the temperature is 65°C; the pressure of the separation tank II is 7MPa, and the temperature is 45°C; under the above conditions, supercritical CO 2 After 3 hours of fluid extraction, the final remaining substances in the separation tank I and the separation tank II are co...

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Abstract

The invention relates to a process for preparing alpha- glucosidase depressant from Cinnamomum cassia, which comprises removing low-polarity constituents with no inhibiting activity to alpha-glucosidase from Cinnamomum cassia by means of fluid extraction technique, and carrying out solid-liquid oscillation extraction to the residual of extracting with anhydrous alcohol. The extracted effective portion has rather strong inhibiting activity to alpha-glucosidase.

Description

technical field [0001] The invention relates to a method for extracting alpha-glucosidase inhibitors from Chinese medicine cinnamon, and belongs to the technical fields of Chinese herbal medicine preparation and chemical engineering. Background technique [0002] Cinnamon, also known as cinnamon, cinnamon, etc., is a commonly used traditional Chinese medicine and food supplement, and has no toxic and side effects on human health. The traditional Chinese medicine cinnamon is derived from the dried bark of the lauraceae plant cinnamon. Cinnamon has the effects of tonifying fire and supporting yang, drawing fire back to its source, dispelling cold and relieving pain, promoting blood circulation and stimulating menstruation. In recent years, it has been found that cinnamon also has the effect of preventing diabetes, but there is no report on the study of extracting α-glucosidase inhibitors from cinnamon and conducting research on the hypoglycemic effect. [0003] At present, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P3/10A61K129/00
Inventor 雍克岚吕敬慈张忠陈旭
Owner SHANGHAI UNIV
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