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Method for preparing nicorandil tablet

A nicorandil tablet and nicorandil technology are applied in the field of drug preparation to achieve the effects of reducing the generation of harmful impurities, reducing the occurrence of adverse reactions and ensuring safety

Inactive Publication Date: 2006-10-04
XIAN LIBANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The result of the novelty search is: "There is no preparation process of nicorandil introduced in relevant domestic and foreign literatures similar to the production of nicorandil tablets by the direct powder compression method of the novelty search project; the production of nicorandil tablets by dry granulation technology; Related reports on the production of nicorandil tablets by blank granule compression method”

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Preparation of nicorandil tablets with a main drug dosage of 0.5%

[0018] Name

[0019] Preparation method: Weigh the ingredients according to the prescription, mix them evenly, and press tablets to get, each tablet weighs about 500mg, and each tablet contains 2.5mg nicorandil.

Embodiment 2

[0020] Example 2: Preparation of nicorandil tablets with a main drug dosage of 6.25%

[0021] Name

[0022] Preparation method: Weigh the ingredients according to the prescribed amount, mix them, and press tablets to get, each tablet weighs about 40mg, and each tablet contains 2.5mg nicorandil.

Embodiment 3

[0023] Example 3: Preparation of Nicorandil tablets with a main drug dosage of 8.3%

[0024] Name

[0025] Preparation method: Weigh the ingredients according to the prescribed amount, mix them, and press tablets to get, each tablet weighs about 60mg, and each tablet contains 5mg nicorandil.

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PUM

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Abstract

The invention discloses a process for preparing Nicorandil tablets through charging diluent, binding agent, crumbling agent, lubricating agent, flow adjuvant and anti-oxidizing agent into 0.5-25.0 wt% of Nicorandil. The tablets can be prepared through direct powder pelleting method, dry method granulation pelleting or blank granulation method.

Description

Technical field [0001] The invention relates to a method for preparing a medicine, in particular to a method for producing nicorandil tablets by adopting a powder direct compression technique or a dry granulation technique or a blank granule method. The method can prevent the degradation of nicorandil under the influence of moisture and heat, and can improve the product quality and the safety of patients' medication. Background technique [0002] Nicorandil, also known as Yanlang Ding and Nicotinyl, is a nitrate compound. It is the only drug for the treatment of coronary heart disease and angina pectoris that has a dual mechanism of action among the cardiovascular drugs currently on the market. It not only has the effect of nitrate ester drugs to dilate coronary arteries, continuously increase coronary blood flow, inhibit coronary artery spasm, but also prevent the release of intracellular calcium ions and increase the permeability of cell membranes to pota...

Claims

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Application Information

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IPC IPC(8): A61K31/455A61K9/20A61P9/10A61P7/02
Inventor 胡忍乐鲁会侠王九成黄馨慧
Owner XIAN LIBANG PHARMA TECH
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