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Chinese medicinal gel formulation, its preparation process and quality control method

A technology for gel preparations and traditional Chinese medicines, which is applied in the direction of testing pharmaceutical preparations, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of prolonging the retention time of drugs in the cornea, poor drug absorption, and short drug retention time. Good economic and social benefits, easy absorption, long residence time

Inactive Publication Date: 2006-07-12
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used ophthalmic dosage form in clinical practice is eye drops, but in clinical application, it is found that eye drops have the disadvantages of short retention time of drugs in the eyes and poor drug absorption. Therefore, the above drugs were prepared into eye drops in this study. With the gel, the preparation can overcome the shortcomings of ordinary eye drops that tears can speed up the drug elimination, prolong the residence time of the drug in the cornea, so as to achieve the purpose of increasing drug absorption and prolonging the action time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Prescription: bear bile powder 3g natural borneol 1.0g

[0043] Preparation method: take bear bile powder, add 10 times the amount of distilled water to dissolve, add ethanol to the alcohol concentration of 50%, reflux for 1 hour, filter, evaporate the filtrate to dryness under reduced pressure, crush it, and set aside; take natural borneol and dissolve it in 10 times the amount Add the same amount of distilled water to the ethanol, and after the microcrystals are precipitated, filter, rinse the microcrystals with distilled water until there is no alcohol smell, and set aside; soak 2g of carbomer in 500ml of distilled water, and place it overnight until the matrix is ​​completely moistened. Add the pH regulator boric acid and borax to it, stir evenly, and control the pH value to 5-7, then mix the extracted and refined bear bile powder, natural borneol extract, ethylparaben, and glycerin, and mix evenly. Then mix the above two liquids evenly, add distilled water to 1000m...

Embodiment 2

[0045] Prescription: bear bile powder 3g natural borneol 1.0g

[0046] Preparation method: take bear bile powder, add 10 times the amount of distilled water to dissolve, add ethanol to the alcohol concentration of 50%, reflux for 1 hour, filter, evaporate the filtrate to dryness under reduced pressure, crush it, and set aside; take natural borneol and dissolve it in 10 times the amount Add the same amount of distilled water to the ethanol, and after the microcrystals are precipitated, filter, rinse the microcrystals with distilled water until there is no alcohol smell, and set aside; soak 2g of hypromellose in 500ml of distilled water, and place it overnight until the matrix moistens Completely, finally mix the extracted and refined bear bile powder and natural borneol extract, boric acid, borax, ethylparaben, glycerin, and then mix the above two liquids evenly, add distilled water to 1000ml, and stir well , sterilized, coarsely filtered and then finely filtered to obtain a tr...

Embodiment 3

[0048] Prescription: bear bile powder 3g natural borneol 1.0g

[0049] Preparation method: take bear bile powder, add 10 times the amount of distilled water to dissolve, add ethanol to the alcohol concentration of 50%, reflux for 1 hour, filter, evaporate the filtrate to dryness under reduced pressure, crush it, and set aside; take natural borneol and dissolve it in 10 times the amount Add the same amount of distilled water to the ethanol, and after microcrystals are precipitated, filter, rinse the microcrystals with distilled water until there is no alcohol smell, and set aside; first soak 3g of chitosan in 500ml of distilled water, add boric acid to dissolve it, Then mix the extracted and refined bear bile powder with natural borneol extract, boric acid, borax, ethylparaben, and glycerin, and finally mix the above two liquids evenly, add distilled water to the full amount, sterilize, and stir thoroughly. First coarse filtration and then fine filtration to obtain a transparen...

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Abstract

The invention provides a traditional Chinese medicinal gelling agent, which comprises bear gall powder and natural ice as the main medicaments, as well as right amount of medicinal adjuvant including gel base material, isotonic conditioning agent, pH regulator and distilled water. The invention also discloses the process for preparing the gel and the control method.

Description

technical field [0001] The invention relates to a traditional Chinese medicine gel preparation and a preparation method thereof, which is applied to the treatment of ophthalmic diseases and belongs to the technical field of traditional Chinese medicine preparation technology. Background technique [0002] Gel is a new form of traditional Chinese medicine. In this study, the traditional Chinese medicine gel was prepared by combining the traditional Chinese medicine bear bile powder and natural borneol. Inflammation, epidemic keratoconjunctivitis, etc. At present, the commonly used ophthalmic dosage form in clinical practice is eye drops, but in clinical application, it is found that eye drops have the disadvantages of short retention time of drugs in the eyes and poor drug absorption. Therefore, the above drugs were prepared into eye drops in this study. With the gel, the preparation can overcome the shortcoming that ordinary eye drops tears can speed up the drug elimination...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/00A61P31/04A61P29/00A61P27/02G01N30/90G01N33/15
Inventor 代龙
Owner 北京凯瑞创新医药科技有限公司
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