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Preparation and application of anti blocking biomembrane for tendon and ligament

A biofilm and anti-adhesion technology, applied in the field of medical biomaterials, can solve the problems of ineffective treatment and achieve reliable curative effect, convenient use and stable molecular structure

Active Publication Date: 2006-07-05
于海鹰 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the therapeutic effects of dexamethasone hormone, bioprotein glue and other materials used clinically are not obvious, and cannot effectively prevent the formation of adhesions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0007] The biofilm which uses type I collagen as a material to prevent tendon and ligament adhesion provided by the present invention has been proved to have remarkable anti-adhesion effect in animal experiments. The specific implementation method is: use bovine tendon as the base material, undergo acid, alkali, enzyme treatment and sulfate cartilage crosslinking, freeze-dry and sterilize to make a sponge-like protein with a protein purity of more than 95%, a pore size of 146 μm, and a thickness of 0.2 mm. Type I collagen anti-adhesion biofilm is ready for use; after the animal’s injured limb tendons and ligaments are surgically sutured, a 20×30mm anti-adhesion biofilm is directly wrapped around the damaged tendon or ligament in a tubular form; then the skin is sutured and combined Play plaster. Two weeks after the operation, the injured limbs were passively moved, the plaster was removed around them, and the injured limbs were continued to be passively moved. Animals were sa...

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Abstract

An anti-adhesion biological membrane for muscle tendon and ligament is prepared from the muscle tendon of beef through removing impurities, washing, treating with acid, alkali and enzyme, cross-linking with chondroitin sulfate, and freeze drying. Its advantages are high structure stability, biocompatibility and degradability. It is applied by winding it on the clean muscle tendon or ligament after operation to form a false membrane.

Description

Technical field: [0001] The invention relates to the technical field of medical biomaterials, in particular to the preparation and application of a biofilm for tendon and ligament injury and postoperative adhesion prevention. Background technique: [0002] With the advancement of medical science and technology and the continuous development of medical materials, collagen-based products in the medical field have achieved remarkable development in recent years, such as the Chinese patent, the patent number is 021212779, and the patent name is medical collagen material and its The manufacturing process discloses a medical collagen material, which uses bovine tendon tissue as the base material, and undergoes processes such as impurity removal, cleaning, acid, alkali, enzyme treatment, sulfuric acid cartilage agent cross-linking, freeze-drying, and ethylene oxide sterilization. It is made of porous and spongy medical collagen material, which has the characteristics of stable stru...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L31/04A61L31/10
CPCA61K38/39A61L31/044
Inventor 于海鹰许和平
Owner 于海鹰
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