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Freeze-dried powder-injection of methionine vitamin B1, and its prepn. method

A technology of freeze-dried powder injection and methionine, which is applied in the field of methionine vitamin B1 pharmaceutical preparations, can solve problems such as reduced stability, increased toxic and side effects, and influence on drug efficacy, and achieves good resolubility and reasonable formulation. , good stability

Inactive Publication Date: 2006-06-14
王海燕 +1
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0009] However, the methionine vitamin B currently used in the market 1 Due to the hydrolysis of methionine and other reasons, the stability of the injection is reduced, and it is easy to cause quality problems during storage and transportation, affecting the efficacy of the drug, and in severe cases, it will also lead to increased toxicity and side effects

Method used

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  • Freeze-dried powder-injection of methionine vitamin B1, and its prepn. method

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Experimental program
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Embodiment Construction

[0038] The preparation process is as follows:

[0039] Take by weighing methionine 40g by embodiment 1 prescription, vitamin B 1 4g, put it in a clean container, add 800ml of water for injection, heat and stir to keep the temperature of the aqueous solution at 45°C, add 0.4g of charcoal for needles, stir for 20 minutes, and decarbonize by coarse filtration. The measured pH of the solution is 4.2, and use 0.1 mol / L sodium hydroxide solution to adjust the pH value to 4.8, add water for injection to the prescription amount, filter with a 0.22 micron microporous membrane, check the intermediate content, then fill the filtrate in a 7ml / support vial, 1ml vial, stoppered, freeze-dried, filled with nitrogen, corked and packaged.

[0040] Methionine

Vitamin B 1

Add water for injection to

100g

10g

2000ml

Co-made

1000 bottles

[0041] The preparation process is as follows:

[0042] Take by weighing methionine 100g by embodime...

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Abstract

A freeze-dried powder injection for treating acute an chronic hepatitides, hepatocirrhosis and fatty liver is proportionally prepared from methylthio-amino acid, VB1, auxiliary for the freeze-dried powder injection, and the water for injection. Its preparing process is also disclosed.

Description

technical field [0001] The present invention relates to methionine vitamin B 1 Pharmaceutical preparation, specifically a kind of methionine vitamin B for injection 1 Freeze-dried powder injection and its preparation method. Background technique [0002] Fatty liver is a common clinical disease today, and middle-aged people are a large group of patients. There are many reasons for fatty liver, such as nutritional disorders (excess or deficiency), heavy drinking, drug poisoning, pregnancy and many chronic diseases. About half of fatty liver patients have no obvious symptoms, and common manifestations are: dull pain and discomfort in the liver area, loss of appetite, nausea, abdominal distension, weight loss, etc. Fatty liver may lead to liver cirrhosis. According to statistics, nearly 60% of long-term alcohol drinkers develop fatty liver, and 20% to 30% will eventually develop into liver cirrhosis. For non-alcoholic fatty liver, the probability of liver fibrosis is 25%, w...

Claims

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Application Information

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IPC IPC(8): A61K31/51A61K9/19A61P1/16
Inventor 王海燕
Owner 王海燕
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