Ftibamzone eyedrops

A technology of eye drops and phthalocyanine, which is applied in the directions of drug delivery, organic active ingredients, sensory diseases, etc., can solve the problems of instability and instability of aqueous solutions, and achieve the effects of excellent effect, easy absorption and strong inhibitory effect.

Inactive Publication Date: 2006-05-24
武汉五景药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The aqueous solution of Phthalin is usually unstable, especially in the light and heat environment

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0018] The present invention is further illustrated by the following examples, but not as a limitation of the present invention.

[0019] Consumption per 10,000 sticks

[0020] 2. Process

[0021] (1) Dissolve sodium hyaluronate or other thickeners in 8-10L of water for injection, and filter;

[0022] (2) Add (1) to 30L water for injection, raise the temperature to above 95°C, add the prescribed amount of edetate disodium / edetate dipotassium, Tween-80, keep warm for 30 minutes, then lower the temperature to about 80°C;

[0023] (3) Weigh the phthalobutanol raw material and mix it with 3-5mm glass beads, add a small amount of fresh water for injection to moisten it, put it into a sand mill and grind it for 30 minutes. After meeting the requirements, pour it into 260-mesh nylon cloth, wash and filter it completely with fresh water for injection, and add it to (2);

[0024] (4) 2L water for injection dissolves the preservative;

[0025] (5) Combine (2)(3)(4), and ...

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PUM

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Abstract

The present invention relates to a kind of ftibamzone eye drops. It contains the components of ftibamzone, osmotic pressure regulating agent, preservative, Tween 80, thickening agent, EDTA and sodium hydroxide.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation of phthalobutamol, in particular to a preparation of phthalobutamol eye drops. The preparation can be used for treating various trachoma; keratitis. Background technique: [0002] Phthalin, English name: Ftibamzone, chemical name is 3-phthalimido-2-oxobutyraldehyde-1,2-bisthiosemicarbazone and inclusion of dioxane. Molecular formula: C14H15N702S2 Molecular weight: 377.45 Phthalin is an antiviral drug. Has anti-Chlamydia trachomatis and anti-herpes virus activity. Its mechanism of action is mainly to inhibit viral DNA and early protein synthesis. Phthalidine cannot directly inhibit herpesvirus type II DNA polymerase, nor can it directly inactivate herpesviruses. Phthaltin has certain antifungal effect on dermatophytes. The aqueous solution of Phthalidin is usually unstable, especially in the environment of light and heat. The aqueous solution of phthalobutanol will degrade over time to produce...

Claims

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Application Information

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IPC IPC(8): A61K31/405A61K9/08A61P27/02A61P31/22
Inventor 范先甲范新兰
Owner 武汉五景药业有限公司
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