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Chinese medicinal preparation for accelerating alcohol metabolism

A technology for traditional Chinese medicine preparations and ethanol metabolism, which can be applied to medical preparations containing active ingredients, drug delivery, drug combinations, etc.

Inactive Publication Date: 2006-04-26
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] From the published reports, it is known that Hovenia dulcis fruit extract can accelerate the metabolic rate of ethanol in the body, kudzu flower can also accelerate the metabolic rate of ethanol in the body, and metadoxine capsules can accelerate the metabolic clearance of ethanol, but three The action sites of both are relatively single, and the effect is limited; Pueraria japonica should not be used in large amounts, otherwise there will be safety problems
In addition, Polygonum cuspidatum decoction can restore liver function and subside jaundice by promoting the recovery and regeneration of liver cells and reducing inflammation. Rich in volatile oils such as bornyl acetate, but there is no report that Polygonum cuspidatum, Rhizoma Imperatae, and Amomum directly accelerate the metabolism of ethanol in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Set up normal group, model group, Chinese medicine preparation intervention group of the present invention altogether three groups, except normal group, model group and Chinese medicine preparation intervention group of the present invention all reproduce the alcoholic liver injury model of rats by ethanol gavage method, in the reproduction model Simultaneously, the traditional Chinese medicine preparation intervention group of the present invention was given the traditional Chinese medicine preparation intervention (0.3g / KgBW) by intragastric administration, and both modeling and intervention continued for 42 days. Afterwards, the ethanol concentration in the blood was detected by the dual-wavelength method; in the liver tissue homogenate according to the kit prompt method: coomassie leucocyanin, malondialdehyde, triglyceride, superoxide dismutase, glutathione peroxidase ; Detection of alcohol dehydrogenase in liver tissue homogenate by activity spectrophotometry; Fluor...

Embodiment 2

[0011] The effect of increasing alcohol consumption and improving the discomfort after drinking was evaluated by scoring scale in 29 human subjects. The result is: 29 examples of people who try Chinese medicine preparations of the present invention (capsules, 6 capsules / person / time, 0.3g / capsule), the total amount of alcohol consumed during the test increased by 3710g, and the increase rate was 75.56%, and the average amount of alcohol consumed increased by 75.56% than usual. 127.83g / time / person; the results show that: 65.52% of people can increase the amount of drinking, 44.83% of people can improve the discomfort after drinking, the total effective rate of increasing the amount of drinking and improving the discomfort after drinking is 86.21%; it can increase the amount of drinking In the total points that can improve the comprehensive score of alcohol discomfort, the effective number is more than the invalid number, and the difference is significant (p<0.05).

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Abstract

Disclosed is a Chinese medicinal preparation for accelerating alcohol metabolism, which comprises the following components (by weight percentage): hovenine seed 25-75%, giant knotweed rhizome 15-35%, cogongrass rhizome 5-25%, and amomum fruit 5-15%.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, more specifically, the invention relates to a traditional Chinese medicine preparation with the function of accelerating ethanol metabolism. Background technique [0002] From the published reports, it is known that Hovenia dulcis fruit extract can accelerate the metabolic rate of ethanol in the body, kudzu flower can also accelerate the metabolic rate of ethanol in the body, and metadoxine capsules can accelerate the metabolic clearance of ethanol, but three The action sites of both are relatively single, and the effect is limited; Pueraria japonica should not be used in large amounts, otherwise there will be safety problems. In addition, Polygonum cuspidatum decoction can restore liver function and subside jaundice by promoting the recovery and regeneration of liver cells and reducing inflammation. Rich in volatile oils such as bornyl acetate, but there...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61K9/00A61P1/16
Inventor 张立实潘年松
Owner SICHUAN UNIV
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