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Antiflatulents in combination with histamine H1-receptor antagonists for treating gastrointestinal disorders

A technology for gastrointestinal diseases and receptor antagonists, which is applied in the field of compositions for the treatment of gastrointestinal diseases, and can solve problems such as increasing the risk of gastrointestinal cancer

Inactive Publication Date: 2006-04-19
LIFESCAPE BIOSCIENCE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

IBD often increases risk of gastrointestinal cancer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The aforementioned pediatric and adult formulations are prepared by methods well known in the art of pharmacy.

[0079] The pediatric formulation provides active ingredient doses, including 40mg / 0.6ml difoam and 1.25mg / 0.6ml diphenhydramine. A typical daily dose for relief of pain and / or discomfort from colic in an infant weighing 5kg (11Ib) is approximately 0.6ml (approximately half a dropper) taken four times daily every four (4) to six (6) hours. For infants weighing approximately 5-10 kg (11-22 Ib), a typical dose is approximately 1.2 ml (approximately 1 dropper) taken every four (4) to six (6) hours four times daily.

[0080] The adult formula provides a dose of active ingredient for the relief of pain and / or discomfort of gastrointestinal disorders in adults with a body weight of about 50kg to about 100kg, comprising about 80mg / 5ml (1 teaspoon) to about 160mg / 10ml (2 teaspoons) Antifoam and about 6.25mg / 5ml (1 teaspoon) - about 12.5 / 10ml (2 teaspoons) of d...

Embodiment 2

[0083] The aforementioned pediatric and adult formulations are prepared by methods well known in the art of pharmacy.

[0084] The pediatric formulation provides active ingredient doses comprising about 40 mg / 0.6 ml of defoamer, about 1.25 mg / 0.6 ml of diphenhydramine, and about 20 mg / 0.6 ml of larch arabinogalactan. A typical daily dose for relief of pain and / or discomfort from colic in an infant weighing 5kg (11Ib) is approximately 0.6ml (approximately half a dropper) taken four times daily every four (4) to six (6) hours. For infants weighing approximately 5-10 kg (11-22 Ib), a typical dose is approximately 1.2 ml (approximately 1 dropper) taken every four (4) to six (6) hours four times daily.

[0085] The adult formula provides a dose of active ingredient for the relief of pain and / or discomfort of gastrointestinal disorders in adults with a body weight of about 50kg to about 100kg, comprising about 80mg / 5ml (1 teaspoon) to about 160mg / 10ml (2 teaspoons) Antifoam,...

Embodiment 3

[0088] The aforementioned pediatric and adult formulations are prepared by methods well known in the art of pharmacy.

[0089] The pediatric formulation provides active ingredient doses comprising about 40 mg / 0.6 ml of diphenhydramine, about 1.25 mg / 0.6 ml of diphenhydramine, and about 6 mg / 0.6 ml of a probiotic blend. A typical daily dose for relief of pain and / or discomfort from colic in an infant weighing 5kg (11Ib) is approximately 0.6ml (approximately half a dropper) taken four times daily every four (4) to six (6) hours. For infants weighing approximately 5-10 kg (11-22 Ib), a typical dose is approximately 1.2 ml (approximately 1 dropper) taken every four (4) to six (6) hours four times daily.

[0090] The adult formula provides a dose of active ingredient for the relief of pain and / or discomfort of gastrointestinal disorders in adults with a body weight of about 50kg to about 100kg, comprising about 80mg / 5ml (1 teaspoon) to about 160mg / 10ml (2 teaspoons) Antifoa...

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PUM

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Abstract

Compositions and methods for providing relief from pain and / or discomfort associated with gastrointestinal disorders, including, for example, bloating, crying, gas, cramping, regurgitation, diarrhea and gastrointestinal pain, associated with colic comprising, at least one antiflatulent, at least one histamine H1-receptor antagonist, and optionally,one or more prebiotic and / or one or more probiotic.

Description

[0001] This application claims priority to US Provisional Application No. 60 / 455,417, filed March 18, 2003, which is incorporated herein by reference. Field of Invention [0002] The present invention relates to compositions and methods for treating disorders of the gastrointestinal tract. More specifically, the present invention relates to compositions and methods for relieving pain and / or discomfort associated with acute abdominal pain. It also relates to compositions and methods for relieving pain and / or discomfort associated with inflammatory bowel disease and infectious diarrhea. Background technique [0003] Acute colic is a self-limited developmental gastrointestinal disorder affecting approximately twenty percent (20%) of infants. Although the cause of colic is not fully understood, medical experts believe that the sluggishness of symptoms may be related to an immature digestive system, allergic reactions, hormones in breast milk, and overfeeding. Acute colic is a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/135A61K31/715A61K31/716A61K31/733A61K31/80A61K35/74A61K36/00A61K45/06A61P1/00A61P1/04A61P1/06A61P1/12A61P1/14A61P1/16A61P1/18A61K35/741
Inventor 大卫·伯勒尔
Owner LIFESCAPE BIOSCIENCE INC
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