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Plastic made non-grating type surface plasma excimer resonant optic coupler

A technology of polariton resonance optics and surface plasmons, applied in scientific instruments, material analysis through optical means, instruments, etc., to achieve the effect of simple practical operation and accelerated detection speed

Inactive Publication Date: 2006-03-22
HUAZHONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually, methods such as using glass to increase the refractive index of the prism and increasing the wavelength of the light that excites the plasmon are used to suppress this interference signal, but these methods cannot fundamentally solve the problem, and it is necessary to use hardware and software from the SPR spectrum Extraction of signals from biomacromolecular reactions

Method used

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  • Plastic made non-grating type surface plasma excimer resonant optic coupler
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  • Plastic made non-grating type surface plasma excimer resonant optic coupler

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Embodiment 1

[0017] figure 2 Represents an integrated optical coupler made of plastic with angle-scanning surface plasmon resonance of the present invention. Its main part 2 is made of polystyrene with a refractive index of 1.58, above which is an integrated sample cell 8, the bottom of the sample cell is plated with a 50 nm thick gold film, and the gold film is covered with a corresponding biochemical sensitive film according to the detection requirements , becoming a surface plasmon optical coupler integrating prism, gold film and sensitive film. It is connected and positioned by the positioning groove 12 and the positioning hole 13 with the rotating operation platform, which is convenient for moving or replacing, and realizes fast and timely detection.

Embodiment 2

[0019] image 3 Represents a surface plasmon resonance optical coupler with 5 sample cells of the present invention. These multiple sample pools can be coated with different sensitive films according to the needs, so as to achieve the purpose of completing multiple different tests on a certain sample at the same time; they can also be coated with the same sensitive film, so as to achieve the purpose of doing the same or comparative tests on different products. Apparently, increasing the number of sample pools can further reduce the actual cost of the optical coupler of the present invention, which is conducive to the realization of real-time rapid biochemical testing and the application and promotion of SPR detection technology.

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Abstract

The present invention makes non-grating surface plasmon resonance (SPR) optical coupler with plastic to replace optical glass, and belongs to the field of waveguide optics and biological sensing technology. The disposable low cost optical coupler made with low refractive index plastic has low cost, less noise, raised SPR biosensor S / N ratio, convenient instrument operation, and convenient integration with other parts. The SPR biosensor of the present invention may be used in clinical detection, sanitary environment monitoring, industrial production and basic life science research relative to mutual action of macro biomolecules.

Description

technical field [0001] The invention belongs to the intersection field of waveguide optics and biosensing technology, in particular an integrated non-grating surface plasmon resonance (Surface Plasmon Resonance, SPR) optical coupler made of non-glass material—plastic. Background technique [0002] Living organisms are the result of the interaction of biological macromolecules such as proteins and nucleic acids in a certain time sequence and in a specific space. Since the geometric scale of biomacromolecules is on the nanometer scale, in basic life science research and clinical medical testing, in order to quantitatively analyze the interaction of biomacromolecules, it is usually necessary to use specific substances such as radioactive elements, fluorescent substances or enzymes to label the studied substances. Objects, so that the interaction of biological macromolecules such as antigen-antibody reactions and DNA hybridization produces physical phenomena that can be perceive...

Claims

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Application Information

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IPC IPC(8): G01N21/41G01N21/55G01N21/552
Inventor 肖才德刘武刘晓东马宁
Owner HUAZHONG NORMAL UNIV
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