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Cervus and cucumis polypeptide injection composition and preparing method

A deer melon polypeptide and technology for injection, which is applied in the preparation of deer melon polypeptide pharmaceutical composition for injection, and in the field of deer melon polypeptide pharmaceutical composition for injection, can solve problems such as inconsistency, and achieve the goal of inhibiting release, promoting recovery, and promoting synthesis Effect

Active Publication Date: 2006-03-08
黑龙江迪龙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most amino acids are easy to precipitate in alkaline solutions, and the above-mentioned technologies all use alkaline pH values ​​in the extraction process, which are inconsistent with national drug standards.

Method used

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  • Cervus and cucumis polypeptide injection composition and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1: the preparation of deer bone extract solution

[0086] Boil the deer bones in boiling water for 30 minutes, take them out, remove the fascia and residual meat, and obtain the deer bones. Take the deer bone and crush it to a size less than 1cm for later use. Take 30kg of broken bones, add 60kg of water for injection, extract by hot pressing at 121°C for 2 hours, and filter out the primary extract; then add 60kg of water for injection, extract by hot pressing at 121°C for 2 hours, filter out the second extract, combine the filtrates, and let them stand overnight. Take the deer bone extract, centrifuge (4000 rpm, 15 minutes), take the supernatant, and discard the precipitate. Take the supernatant, and carry out graded ultrafiltration, 100KD, 10KD, 6KD, take the filtrate each time, and discard the concentrate. Take the filtrate, concentrate under reduced pressure to 10% of the total volume, collect the concentrated solution, adjust the pH value to 6.0-6.5, ...

Embodiment 2

[0088] Embodiment 2: the preparation of muskmelon seed extract solution

[0089]Take the melon seeds, put them in water for injection, rinse repeatedly 3-4 times, dry the water, pick out the sundries, and get the clean melon seeds for later use. Take 15kg of clean melon seeds, add 30kg of water for injection, and grind them into a homogenate of melon seeds with a colloid mill. Take melon seeds homogenate, extract by hot pressing at 121°C for 2 hours, and filter out the primary extract; then add 30kg of water for injection, continue to extract by hot pressing at 121°C for 2 hours, filter out the second extract, combine the filtrates, and leave overnight. Take the melon seed extract, centrifuge (4000 rpm, 15 minutes), take the supernatant, and discard the precipitate. Take the supernatant, and carry out graded ultrafiltration: 100KD, 10KD, 6KD, take the filtrate each time, and discard the concentrate. Take the final filtrate, concentrate under reduced pressure to 10% of the ...

Embodiment 3

[0091] Embodiment 3: pharmaceutical composition 1

[0092] Preparation prescription:

[0093] The deer bone extract solution 26.7g of embodiment 1 (calculated by deer bone polypeptide)

[0094] Melon seed extract solution 13.3g (calculated by the melon seed polypeptide) of embodiment 2

[0095] 20% excipient solution 5000ml

[0096] 5% NaOH (or 5% HCl) appropriate amount

[0097] Add water for injection to 20000ml

[0098] The deer bone extract solution prepared in Example 1 and the melon seed extract solution prepared in Example 2 were mixed according to the weight ratio of deer bone polypeptide and melon seed polypeptide in a ratio of 2:1, and 5000ml of excipient (dextran 40, glucose or lactose) solution was added , adjust the pH value of the solution to 5.5-7.0 with an appropriate amount of 5% NaOH or 5% HCl, then add water for injection to the full amount, and make a 4 mg preparation by filling, freeze-drying, capping and other steps.

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Abstract

The present invention discloses a deer's bone melon seed polypeptide medicine composite. It is made up by using deer's bone extract, melon seed extract and one or several excipients, in which the weight ratio of deer's bone polypeptide and melon seed polypeptide is 2:1 to 6:1. Said polypeptide medicine composite can be used as injection preparation.

Description

technical field [0001] The invention relates to a medicinal composition of lugua polypeptide for injection and a preparation method thereof. More specifically, the present invention relates to a pharmaceutical composition of deer melon polypeptide for injection containing deer bone polypeptide and melon seed polypeptide. The present invention also relates to a preparation method of the medicinal composition of fenugreek polypeptide for injection. Background technique [0002] Deer melon polypeptide is formulated with deer bone and melon seed extracts. Chinese medicine believes that deer bone is sweet and slightly hot. Sanjie, relieve pain and other effects, the two preparations are used for dispelling cold, dispelling rheumatism, and analgesia, so they have a therapeutic effect on rheumatoid arthritis or rheumatoid arthritis. [0003] In the prior art, some related velvet melon polypeptide extracts and its preparation process have been disclosed. For example, CN1470256A d...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61K35/32A61K38/16A61P29/00A61P19/02
Inventor 王金富
Owner 黑龙江迪龙制药有限公司
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