Analyzing system and analysing method based on integrated micro-flow control chip

A microfluidic chip and analysis system technology, applied in the field of micro-total analysis, can solve problems to be developed, and achieve the effects of simple operation, high sensitivity and fast analysis speed

Inactive Publication Date: 2006-03-01
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

In summary, it describes a new type of device called an integrated microsystems (IMS) chip analyzing system which allows samples containing different substances to be separated into their components before being detected or identified with specific types of molecules attached thereto. Its technical effect lies within its simplicity, low costs compared to other techniques like liquid phase extraction, mass spectrometry, X ray diffraction, nuclear magnetic resonance imaging, and others.

Problems solved by technology

This patented describes how small devices called MicroFluents were introduced that combined different techniques such as liquid chromatoxin assay(LC), immunoflourishment testing, DNA sequencing, protein crystallography, etc., making them more efficient than traditional analytical tools like LC/MS. These systems allow researchers to analyze large amounts of substances quickly while minimizing their impact on healthcare providers' resources. They use tiny components made up of materials to perform specific tasks within one chamber instead of relying upon bulky instruments. Overall, this innovation allows scientists to make faster and better ways to test drug compounds during clinics without having physical contact between patients and medical professionals.

Method used

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  • Analyzing system and analysing method based on integrated micro-flow control chip
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Examples

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Embodiment

[0020] Example: Detection of the stimulant amphetamine in urine by the system. like figure 1 As shown, the microfluidic chip is made of glass, with a length of 5.0 cm, a width of 2.5 cm, a bottom plate with a thickness of 1.0 mm, and a cover plate with a thickness of 0.5 mm. The length of the pretreatment channel 1 is 3 cm, the depth is 100 μm, and the width at half maximum is 180 μm. Separation channel 2 is 4.2 cm long, 100 μm deep, and 125 μm wide at half maximum. The sampling channel is 5 mm long on both sides of the intersection b, and the inner diameter of all liquid storage holes is 2 mm. The distances from the T-shaped intersection a to the liquid storage hole 6 and from the cross intersection b to the liquid storage hole 7 are 3 mm respectively. The pretreatment channel 1 is filled with a dual-phase solid phase carrier: the porous polymer monolithic column 4 (vinyl dimethacrylate and methyl Copolymer of butyl acrylate), and then fill the gas chromatography filler 5...

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Abstract

On the micro-flow control chip a sample pretreatment channel, an electrophoretic separation channel and an electrophoretic sampling channel are integrated, a solid-phase carrier is fixed in the sample pretreatment channel. The actual sample containing components to be analyzed can be undergone the processes of purification, enrichment and fluorescent derivatization reaction in the pretreatment channel, after the fluorescently-labeled product is eluted from solid-phase carrier, it can be introduced into the separation channel to implement chip electrophoretic separation and laser induced fluorescence detection.

Description

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Claims

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Application Information

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Owner FUDAN UNIV
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