Milrinone composition for injection and its prepn
A technology of milrinone and non-injection, which is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, etc.
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Embodiment 1
[0052] Under clean conditions, put 2g of L-aspartic acid into the liquid dispensing device, add 50°C water for injection into 800ml of water for injection and stir to dissolve, cool to room temperature, add 2g of milrinone and stir for about 30 minutes to make it fully dissolved, and put in 40g Dissolve mannitol, add 0.3% needle and stir with charcoal to evenly absorb pyrogen, filter to decarbonize, add water to a sufficient amount, filter through 0.22um microporous membrane to obtain 2 mg / ml milrinone solution. Pack 2.5ml into vials, freeze-dry for 72 hours to make sterile freeze-dried powder injection. The specification is 5mg / bottle.
Embodiment 2
[0054] Dissolve 2g of tartaric acid in 800ml of water for injection in a clean liquid preparation device and stir to dissolve, add 2g of milrinone and stir for about 1 hour to completely dissolve, add 20g of lactose and stir to dissolve, add 0.3% needle and stir evenly with charcoal to absorb pyrogen , decarbonized by filtration, added water to a sufficient amount, and filtered through a 0.22um microporous membrane to obtain a 2 mg / ml milrinone solution. Pack 2.5ml into vials, freeze-dry for 72 hours to make sterile freeze-dried powder injection. The specification is 5mg / bottle.
Embodiment 3
[0056] Under clean conditions, put 2.5g of L-aspartic acid into the liquid dispensing device, add 50°C water for injection into 800ml of water for injection and stir to dissolve, cool to room temperature, add 2.5g of milrinone and stir for about 30 minutes to completely dissolve, Add 50g of mannitol to dissolve, add 0.3% needles and stir with charcoal to evenly absorb pyrogens, filter for decarbonization, add water to a sufficient amount, and filter through a 0.22um microporous membrane to obtain a 2.5mg / ml milrinone solution. Pack 2ml into vials, freeze-dry for 72 hours to make sterile freeze-dried powder injection. The specification is 5mg / bottle.
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