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Novel drug administering route of saussurea involucrate injection and its preparation process

A technology for injections and injections, applied in the new route of administration of Saussurea involucrata injection and its preparation process, which can solve the problems of small dose, slow absorption, secondary infection, etc., and achieve increased anti-inflammatory effects

Inactive Publication Date: 2006-02-15
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, in terms of clinical application, Saussurea involucrata injection adopts the intramuscular injection method, which is absorbed through the tissue, the speed is slow, the dose is small, and the effect on the lesion is small, and it not only increases the pain of the patient, but also causes local induration of the injection, and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of injection of the present invention:

[0039] Prescription: Tianshan snow lotus 500g

[0040] F-68 4g

[0041] Add water for injection to 1000ml

[0042] Preparation:

[0043] Take Tianshan snow lotus, add 85% ethanol to impregnate for 14 days, filter, concentrate the filtrate to contain 1g of the original medicinal material per 1ml, put it in a container for sterilization at 110°C and 0.1kP for 45 minutes, and let it stand for 1 to 3 months. Take this solution and filter, add 4g of F-68 to the filtrate, stir evenly, adjust the pH value to 6.0-8.0 with 40% sodium hydroxide solution, filter with a microporous membrane (0.2μm), add nearly 1000ml of water for injection to the filtrate, Potting, sterilization, that is.

Embodiment 2

[0045] The preparation steps of freeze-dried powder injection of the present invention are as follows:

[0046] Prescription: Tianshan snow lotus 2500g

[0047] F-68 20g Mannitol 50g

[0048] Add water for injection to 1000ml

[0049] Preparation:

[0050] Take Tianshan snow lotus, add 85% ethanol to impregnate for 14 days, filter, concentrate the filtrate to contain 5g of the original medicinal material per 1ml, put it in a container for sterilization at 110°C and 0.1kP for 45 minutes, and let it stand for 1 to 3 months. Take this solution and filter it, add F-68 and mannitol to the filtrate, stir evenly, adjust the pH value to 6.0-8.0 with 40% sodium hydroxide solution, filter it with a microporous membrane (0.2 μm), add water for injection to the filtrate The whole amount, the filtrate is filled in 15ml vials, 2-7ml per bottle. Then place it in a freeze-drying box to pre-freeze for 3 to 5 hours and then vacuumize. After freeze-drying for 24 hours, cork and cap; make fr...

Embodiment 3

[0052] The preparation steps of aseptic powder of the present invention are as follows:

[0053] Prescription: Tianshan snow lotus 2500g

[0054] F-68 20g Mannitol 200g

[0055] Add water for injection to 1000ml

[0056] Preparation:

[0057] Take Tianshan snow lotus, add 85% ethanol to impregnate for 14 days, filter, concentrate the filtrate to contain 5g of the original medicinal material per 1ml, put it in a container for sterilization at 110°C and 0.1kP for 45 minutes, and let it stand for 1 to 3 months. Take this solution and filter, add F-68 and mannitol to the filtrate, stir evenly, adjust the pH value to 6.0-8.0 with 40% sodium hydroxide solution, filter with a microporous membrane (0.2 μm), and use sterile conditions to filter the filtrate Spray in the spray drying tower below to make aseptic powder, sub-package, and label.

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PUM

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Abstract

The invention relates to the novel route for administration of Chinese medicinal injection for treating acute, chronic rheumatic arthritis, rheumatoid arthritis and joint ache caused by ostarthritis, the process for its preparation, and new indications. The injection is prepared from Tianshan snow saussurea as the raw material, and can be made into concentrated solution, freeze-dried powder injection, germ-free powder, 5% glucose injection, and 0.9% sodium chloride injection.

Description

Technical field: [0001] The invention relates to a new administration route and a preparation process of the traditional Chinese medicine preparation Xuelian injection. technical background: [0002] Arthritis generally refers to a group of inflammatory diseases involving joints, that is, the damaged parts of the disease are the joints of the human body, and the joints are red, swollen, hot, painful, inflammatory manifestations of dysfunction, or pathologically, the tissues that make up the joints have degeneration , exudation, and hyperplastic changes are arthritis. In China, there are more than 100 million arthritis patients. Doctors confirm that the number of patients with arthritis is increasing in alarming numbers and that the condition of the disease is rapidly deteriorating. To compound the problem, those who would soon become arthritis sufferers do not know how to prevent it, many sufferers of arthritis are also ignorant of treatments, and some do not even know the...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/08A61K9/19A61P29/00A61P19/02
Inventor 刘露
Owner FUKANGREN BIO PHARMA
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