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Series peptide for promoting proliferation of bone marrow karyota and bone marrow substrate cell and its application

A technology of bone marrow stromal cells and bone marrow nucleated cells, which is applied in the field of biomedicine, can solve problems such as clinical instability, rejection, and large molecular weight of growth factors, so as to solve product instability, avoid rejection, and solve production problems. The effect of complex processes

Active Publication Date: 2006-01-25
福建蓝昊肽生物科技发展有限公司
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Problems solved by technology

Among the technologies that have been published or publicly used, hematopoietic stem cell factor (SCF), granulocyte growth factor (GM-CSF), megakaryoline growth factor (TPO and IL11), erythroid growth factor (EPO) have been used etc., the production of this series of products is mainly realized through complex gene recombination technology, and there are also unstable clinical applications, such as growth factors that are prone to rejection in the human body due to their large molecular weight

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  • Series peptide for promoting proliferation of bone marrow karyota and bone marrow substrate cell and its application
  • Series peptide for promoting proliferation of bone marrow karyota and bone marrow substrate cell and its application
  • Series peptide for promoting proliferation of bone marrow karyota and bone marrow substrate cell and its application

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Embodiment Construction

[0011] The series of peptides for promoting the proliferation of bone marrow nucleated cells and bone marrow stromal cells in this embodiment is characterized in that the series of peptide sequences are: (1) Z-Leu-J-Glu-B-Glu-O-X; (2) Z -Leu-J-Thr-B-O-Tyr-O-Tyr-X; (3) Z-Leu-J-Thr-B-Leu-O-X; (4) Z-Ser-J-Ser-B-Leu-O -Arg-X; (5)Z-Ser-J-His-B-Leu-O-X;

[0012] Among them, Z and X are the auxiliary ligands of this series of peptides, J, O and B each represent amino acids Ser, Lys, Phe, Asn, Leu, Pro, Thr, Arg, Asp, Tyr, Gln, Met, Gly, One of Val, Ile, His, Trp, Glu.

[0013] The above series of peptides were synthesized by Fmoc solid phase synthesis.

[0014] The above-mentioned series of peptides that promote the proliferation of bone marrow nucleated cells and bone marrow stromal cells are mainly used in the treatment of pancytopenia in patients with aplastic anemia and myelosuppression after chemotherapy in cancer patients, including hematopoietic stem cells, progenitor cells,...

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Abstract

The invention relates to a series of peptides capable of promoting the propagation of marrow karyocyte and marrow stroma cell, and its application, its biological activity is superior to the existing hematopoiesis growth factors, and has the advantages of simplified production process and stabilized effect. The medicament can be used for effectively treating panhematopenia for patients with regenerative anemia and cancer.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a series of peptides for promoting the proliferation of bone marrow nucleated cells and bone marrow stromal cells and applications thereof. technical background [0002] Growth factors are a class of substances that regulate cell proliferation and differentiation. Their molecular weights range from several hundred to tens of thousands. They are customarily called polypeptide growth factors. Among the technologies that have been published or publicly used, hematopoietic stem cell factor (SCF), granulocyte growth factor (GM-CSF), megakaryoline growth factor (TPO and IL11), erythroid growth factor (EPO) have been used etc., the production of this series of products is mainly realized through complex gene recombination technology, and there are also unstable clinical applications, such as growth factors that are prone to rejection in the human body due to their large molecular weight. Co...

Claims

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Application Information

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IPC IPC(8): C07K7/08A61K38/08A61P7/06A61P19/10A61P35/00
Inventor 李昊
Owner 福建蓝昊肽生物科技发展有限公司
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