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Production of nanometer heater for tumor magnetic thermal therapy

A heat-generating agent and nanotechnology, applied in heat exchange materials, chemical instruments and methods, etc., can solve the problem of not paying attention to the volume of the reaction system, reduce the magnetic dipole interaction, improve the heating effect, and reduce equipment investment. Effect

Inactive Publication Date: 2005-12-28
SOUTHEAST UNIV
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Problems solved by technology

In addition, judging from the current research situation at home and abroad, the wet chemical co-precipitation method at room temperature can generally only obtain iron oxide particles smaller than 20nm, probably because the reaction system they use is small and the influence of the volume of the reaction system is not noticed.

Method used

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  • Production of nanometer heater for tumor magnetic thermal therapy

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Embodiment Construction

[0024] step 1):

[0025] Preparation of Fe by wet chemical co-precipitation method 3 o 4 Nanoparticles, the reaction is carried out in a 1-liter beaker or a 5-liter beaker or a 50-liter high-speed stirring reactor, and the reaction raw material is FeCl 3 and FeSO4 Press Fe 3+ / Fe 2+ = Mix at a certain ratio between 1.4-1.7 and add to the beaker or reactor, under stirring conditions, add 2.5% ammonia solution into the beaker or reactor through the addition funnel to chemically react with the iron salt until pH = 9, stop adding Ammonia, continue to stir for 1 h and then stop the reaction, and protect the whole reaction process with nitrogen gas.

[0026] Step (2):

[0027] Prepared Fe 3 o 4 Nanoparticles, after washing 3-4 times by magnetic separation, diluted with water to 2-4 g / l water-based Fe 3 o 4 The magnetic liquid is then oxidized with air at 90-100°C, pH = 2-3, and stirred for 4-5 hours to form a water-based γ-Fe 2 o 3 magnetic fluid.

[0028] Step (3):

[...

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Abstract

Production of heating agent for tumor magnetic thermal therapy is carried out by preparing Fe3O4 nanometer particles from wetting chemical coprecipitation, regulating reactant proportion and increasing volume of reacting system to regulate size of Fe3O4 nanometer particles, washing reactant for 3-4 times from magnetic separation, diluting to 2-4g / lwater based Fe3O4 magnetic liquid from water, stirring at 90-100íÒC and pH=2-3, inducing into air, oxidizing for 4-5hrs, forming water based gamma-Fe3O4 magnetic liquid, cooling, adding into glutamic acid 5-10wt%, surface modifying, keeping pH=3+-0.1 and stirring for 4-5hrs, washing for 3-4 times from magnetic separation, obtaining stabilized nanometer heating agent, and dissolving into different concentration 0-20g / l.

Description

technical field [0001] The invention relates to a preparation method of a functional material used for tumor magnetic hyperthermia, and belongs to the technical field of biological and medical nanometer material production. Background technique [0002] Magnetothermal therapy is a promising tumor treatment method under development. It achieves the therapeutic purpose by means of the heating effect of the magnetic material (heating agent) distributed in the tumor tissue in an external alternating magnetic field. kind of. It is generally required that the magnetic material can convert the energy of an external alternating magnetic field to raise the temperature of the tumor tissue to 42-47°C, thereby killing tumor cells. Nanomagnetic particles are easy to disperse and administer, and absorb more magnetic field energy than micron or larger-sized microspheres, which can reduce the requirement for the output power of an external alternating magnetic field, or reduce the dosage, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K5/10
Inventor 顾宁张宇马明
Owner SOUTHEAST UNIV
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