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Polymorphism site and use of schizophrenia relative gene TTR

A technology of polymorphic sites and gene polymorphism, applied in the genetic field of biotechnology, there are few studies that can solve the relationship between TTR gene and schizophrenia, and there are no reports on the correlation of TTR gene with schizophrenia, etc. problem, to achieve the effect of promoting the process and improving the correct rate

Inactive Publication Date: 2005-10-19
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

[0005] After searching domestic and foreign literature and patents of the prior art, there has been no report on the correlation between TTR gene polymorphism sites and schizophrenia, and there are few studies on the association between TTR gene and schizophrenia

Method used

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Embodiment Construction

[0039] Below in conjunction with specific embodiment, to further illustrate the present invention. It should be noted that the following examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0040] 1. Technical route:

[0041] The first step of DNA extraction

[0042] 48 patients with sporadic schizophrenia were collected from Changchun and Jilin, with an average age of 33.5±7.6 years, and 24 of them were female. All patients were strictly diagnosed according to the DSM-IV standard, and signed a unified informed consent form approved by the Shanghai Human Genetic Resources Committee. There were 50 control samples from Xi'an and Jilin, including 22 females, with an average age of 40.2±10.2 years. DNA was extracted from human blood by the conventional phenol-chloroform method, and the concentration was corrected to 10 ng / μl, which was used as a DNA template.

[0043] The second step is to design oligonu...

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Abstract

The present invention discloses one schizophrenia relative gene TTR and its polymorphism site and their use in detecting schizophrenia. The present invention also provides method of detecting mononucleotide polymorphism of the TTR gene. In the said method, the present invention detects four new mononucleotide polymorphism sites and one nonanucleotide deletion site in the site-293 of SEQ ID No. 1 sequence and the site-224, site-265, site-322 and site 352 of SEQ ID No. 2 of the TTR gene. Of them, the SNP1T¿ñA mutation located in the second exon of site-293 will make the amino acid sequence change from glutamic acid to valine and cause change in protein structure and function. The allelic site A, or the allelic site T on the DNA complementary strand is one danger allelic site of leading to schizophrenia and may be used in the diagnosis of schizophrenia.

Description

technical field [0001] The invention relates to a gene TTR related to schizophrenia, a polymorphism site detection method of the TTR gene, and the application of the single nucleotide polymorphism of the TTR gene in diagnosing schizophrenia. It belongs to the genetic field of biotechnology. Background technique [0002] Schizophrenia is a complex mental disease with an incidence rate as high as 1% of the population and consumes a lot of manpower, material and financial resources. Its typical symptoms include positive symptoms such as confusion, hallucinations, delusions, and delusions, and negative symptoms such as social withdrawal, apathy, and volitional decline. Sibling pair analysis, pedigree analysis, and parasite studies consistently show that genetic factors play an important role in the pathogenesis of schizophrenia (BarkurS, Shastry. Schizophrenia: A genetic perspective (Review). Int J Mol Med2002; 9: 207-212) . [0003] Single nucleotide polymorphisms (single nu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 贺林杨异凤万春玲冯国鄞
Owner SHANGHAI JIAO TONG UNIV
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