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Artificial tear and its preparing method

A technology of artificial tears and distilled water, which is applied in the field of medicine, can solve problems such as corneal ulcers, corneal ulcers, and abnormal differentiation of corneal goblet cells, and achieve good antibacterial effects

Inactive Publication Date: 2005-10-05
浙江南洋药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] 5. Vitamin A artificial tears and Youlepe artificial tears produced by Novartis Ophthalmology in Switzerland are used for patients who are ineffective in general artificial tears, which will reduce the number of corneal keratinocytes and increase the number of goblet cells, but corneal ulcers and corneal ulcers may occur after discontinuation of use. Abnormal differentiation and reduction of goblet cells
In addition, the stability and corneal residence time of artificial tears need to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: In this implementation, 1000ml of artificial tears was prepared, which contained 3 g of lactic acid chitosan, 10 g of mannitol, an appropriate amount of sodium lactate, 1.4 g of potassium chloride, an appropriate amount of sodium chloride, and the rest was distilled water.

[0023] Take lactic acid chitosan 3g, mannitol 10g, potassium chloride 1.4g, first lactic acid chitosan is dissolved in 500ml distilled water, then add stabilizer mannitol and osmotic pressure regulator potassium chloride, after completely dissolving, use pH as 14 sodium lactate-sodium hydroxide buffer solution to adjust the pH to 6.0, then add sodium chloride to adjust the osmotic pressure to isotonicity, add distilled water to adjust the volume to 1000ml, and sterilize.

Embodiment 2

[0024] Example 2: In this implementation, 1000 ml of artificial tears were prepared, which contained 8 g of lactic acid chitosan, 12 g of mannitol, an appropriate amount of sodium lactate, 2.0 g of potassium chloride, an appropriate amount of sodium chloride, and the rest was distilled water.

[0025] Take lactic acid chitosan 8g, mannitol 12g, potassium chloride 2.0g, first lactic acid chitosan is dissolved in 500ml distilled water, then add stabilizer mannitol and osmotic pressure regulator potassium chloride, after completely dissolving, use pH as 14 sodium lactate-sodium hydroxide buffer solution to adjust the pH to 7.4, then add sodium chloride to adjust the osmotic pressure to isotonicity, add distilled water to adjust the volume to 1000ml, and sterilize.

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PUM

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Abstract

The present invention relates to an artificial tears. It is made up by dissolving chitosan derivative and auxiliary material in distilled water. The described chitosan derivative is lactic acid chitosan, and its auxiliary material includes stabilizing agent, pH regulating agent and osmoregulating agent. The viscosity and osmotic pressure of said invented artificial tears prepared by using lactic acid chitosan can meet physiological requirement of eye, and said invented artificial tears can have good antibacterial property.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an artificial tear and a preparation method thereof. Background technique [0002] With the development of the times, the improvement of people's living standards, the advancement of technology and the development of computers, people's work and life are increasingly inseparable from computers. However, people face the computer screen for a long time, and often feel discomfort in the eyes, and there is a feeling of astringency and pain. A survey in the United States shows that more than 90% of people who work in front of the computer for more than three hours a day will easily cause dry eye disease, which is manifested as eye fatigue, dryness, and inattention. Dry eye disease is a general term for a group of diseases in which the eye epithelium dries up due to low tear secretion or abnormal tear film caused by other reasons. Clinically, keratitis sicca (keratoc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61P27/04
Inventor 金国建孔繁智马越峰钱青通陈春
Owner 浙江南洋药业有限公司
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