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Prepn process of strontium hydroxyapatite

A technology of strontium hydroxyapatite and strontium salt, applied in dental preparations, pharmaceutical formulas, dental prostheses, etc., can solve problems such as difficult degradation and unfavorable recovery of bone function

Inactive Publication Date: 2005-09-28
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, after being implanted in the organism, it is not easy to degrade for a long time, and remains in the bone defect tissue as a heterogeneous body, which may become a source of infection and an obstacle when some implant devices (such as artificial tooth roots) are implanted. It is not conducive to the recovery of bone function in this part

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0026] Example 1: Add 4.5g strontium chloride, 2.1g calcium oxide to 500ml deionized water, add 1.5ml 85% ethylenediamine aqueous solution to form mixture A; add 2.75g ammonium dihydrogen phosphate to 100ml deionized water, Add 2.5ml of 85% aqueous solution of ethylenediamine to form mixture B. When both A and B are heated to 80°C, add solution B dropwise to solution A stirred at high speed, and adjust the pH value to 10.0 with 85% ethylenediamine. The dropwise addition was completed within 2 hours, stirred at a constant temperature of 70°C for 6 hours, and allowed to stand for 8 hours, the precipitate was filtered, washed, the pH value was about 7, dried at 110°C, and calcined at 750°C for 8 hours to obtain the product. The X-ray diffraction peak is obvious, and the purity of the finished product is average.

example 2

[0027] Example 2: 4.5g of strontium chloride, 3.1g of calcium chloride and 500ml of deionized water were made into a solution, and 1.4ml of n-butylamine was added to form compound A; 2.75g of ammonium dihydrogen phosphate was added to 100ml of deionized water, and stirred Dissolve, add 2.3ml n-butylamine to form solution B. When heating A and B to 80°C, stir A at a high speed and add B dropwise, and adjust the pH value to 9.0 with n-butylamine. The dropwise addition was completed within 1.5 hours, stirred at a constant temperature of 80°C for 8 hours, and allowed to stand for 12 hours, the precipitate was filtered, washed, the pH value was about 7, dried at 110°C, and calcined at 950°C for 4 hours to obtain the product. The X-ray diffraction peak is obvious, and the purity of the finished product is average.

example 3

[0028] Example 3: 5.0g strontium nitrate, 2.7g calcium chloride were added into 500ml deionized water to form a solution, and 1.5ml 85% hexamethylenediamine aqueous solution was added to form mixture A; 2.75g ammonium dihydrogen phosphate was added to 100ml deionized water To make a solution, add 2.5ml of 85% hexamethylenediamine aqueous solution to make mixture B. When heating A and B to 60°C, stir A at a high speed and add B dropwise, and adjust the pH value to 8.5 with hexamethylenediamine. The dropwise addition was completed within 2 hours, stirred at a constant temperature of 95°C for 10 hours, and allowed to stand for 24 hours, the precipitate was filtered, washed, the pH value was about 7, dried at 110°C, and calcined at 1000°C for 4 hours to obtain the product. The X-ray diffraction peaks are average, and the purity of the finished product is average.

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Abstract

The strontium hydroxyapatite is produced with strontium nitrate, strontium chloride, calcium nitrate, calcium chloride, dipotassium hydrogen phosphate, disodium hydrogen phosphate, diammonium hydrogen phosphate, potassium dihydrogen phosphate, sodium dihydrogen phosphate and ammonium dihydrogen phosphate as material, and through stirring in the presence of catalyst and in the condition of heating and sealing, filtering, calcining and other steps. The present invention has yield of 91 %, shortened reaction period, high production efficiency, low production cost, reuse of the mother liquor, and other advantages.

Description

technical field [0001] The invention relates to a preparation method of strontium hydroxyapatite. Background technique [0002] The inorganic mineral composition constituting the living tissue is mainly calcium hydroxyphosphate (hydroxyapatite HAP). The research on hydroxyapatite sintered body as artificial replacement material has made gratifying achievements. However, in addition to fully affirming the good biocompatibility of this material, people also pointed out that although the chemical composition of hydroxyapatite sintered body is very similar to that of biological tissues, its crystallinity and structural stability are lower than those of biological tissues. Hydroxyapatite crystals are high in natural bone. Therefore, after being implanted in the organism, it is not easy to degrade for a long time, and remains in the bone defect tissue as a heterogeneous body, which may become a source of infection and an obstacle when some implant devices (such as artificial too...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61K6/04C04B35/447C04B35/622C04B35/63
Inventor 方岩雄林英光张永成张焜
Owner GUANGDONG UNIV OF TECH
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