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Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry

A spectroscopic and ion mobility technology, applied in electronic/ion optical devices, measurement devices, separation methods, etc., can solve the problem of no net change in ion mobility coefficient, and achieve the effect of avoiding sample cross-contamination and simple mass spectrometry

Inactive Publication Date: 2005-02-23
CHARLES STARK DRAPER LABORATORY
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Problems solved by technology

This results in no net change in the mobility coefficient of the ion

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  • Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry
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  • Methods and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry

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Embodiment Construction

[0116] Preferred embodiments of the present invention are described below.

[0117] The present invention provides a method and apparatus for analyzing compounds in a liquid sample, preferably implemented by a high electric field asymmetric waveform ion mobility spectrometer.

[0118] in such as figure 2 In the illustrative embodiment of the invention shown, chemical sensor system 10 includes sample preparation section 10A, filter section 10B, and output section 10C. In practice, the liquid sample S is ionized in the sample preparation section 10A, the generated ions are then transmitted to the filter section 10B and filtered, and then the ions passing through the filter section are transmitted to the output section 10C for detection. The liquid sample preparation part 10A, the filter part 10B and the output part 10C work under the control and instruction of the controller part 10D. Controller section 10D preferably controls the operation of system 10 and evaluates and repor...

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Abstract

Method and apparatus for the analysis of compounds using electrospray in hihg field asymmetric ion mobility spectrometry.

Description

field of invention [0001] The present invention relates to ion mobility spectrometry for the preparation of gaseous and liquid samples by electrospray sample delivery and using internal or external detectors in a field asymmetric waveform ion mobility spectrometer , filtering, and detection. Background technique [0002] Electrospray mass spectrometry is a powerful analytical tool that is widely used in the structural analysis of biomolecules (ie, proteins, peptides, and DNA). See the article "Electrospray Ionization Mass Spectrometry Fundamental. Instrument and Applications" published in 1997 by Richard B. Cole, John Wiley and Sons. The technique plays an important role in the development of most pharmaceuticals and is being used to quantify human exposure to carcinogens. Due to the size and potential rewards of the pharmaceutical market, interest has been shown and technically enhanced in the development of electrospray mass spectrometry-based instrumentation. [0003] ...

Claims

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Application Information

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IPC IPC(8): G01N27/64H01J49/04H01J49/06H01J49/10H01J49/26H01J49/40H01J49/42
CPCG01N27/624H01J49/165
Inventor 拉安安·A·米勒欧金琼·G·纳泽罗加里·A·埃斯曼埃吉尼·克里洛维
Owner CHARLES STARK DRAPER LABORATORY
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