Medicinal preparation containing erythromycine ethylsuccinate

A technology of erythromycin ethylsuccinate and pharmaceutical preparations, applied in the directions of medical preparations containing active ingredients, antibacterial drugs, pharmaceutical formulations, etc., can solve the problem of successful development of parenteral administration formulations of erythromycin ethylsuccinate. and other problems, to achieve the effect of rapid curative effect, stable performance and low side effects

Inactive Publication Date: 2005-01-12
MICROBIOLOGY INST OF SHAANXI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there have been no relevant literature and product reports on the successful development of parenteral dosage forms of erythromycin ethylsuccinate

Method used

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  • Medicinal preparation containing erythromycine ethylsuccinate
  • Medicinal preparation containing erythromycine ethylsuccinate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Component Specification mg

[0020] erythromycin ethylsuccinate Lijun Group 10

[0021] Hydroxypropyl Beta Cyclodextrin Shaanxi Institute of Microbiology 500

[0022] Glucose Chinese Pharmacopoeia 2000 490

[0023] Total 1000

[0024] Add hydroxypropyl beta-cyclodextrin to 5ml of water under stirring conditions, and continue to stir until it is completely dissolved; add ethylsuccinate and stir until it is completely dissolved; microwave treatment in an ice bath for 2 minutes; the resulting solution is sterilized with 0.2 mm nylon membrane filter; add medicinal glucose powder, stir until dissolved; after freeze-drying, it can be packaged and used.

Embodiment 2

[0026] Component Specification mg

[0027] erythromycin ethylsuccinate Lijun Group 50

[0028] Hydroxypropyl Beta Cyclodextrin Shaanxi Institute of Microbiology 500

[0029] Total 550

[0030] Add hydroxypropyl beta-cyclodextrin to 5ml of medicinal absolute ethanol under stirring conditions, and continue to stir until completely dissolved; add ethylsuccinate and stir until completely dissolved; the resulting solution is sterilized by filter membrane; After being freeze-dried, it can be packaged and used.

Embodiment 3

[0032] Component Specification mg

[0033] erythromycin ethylsuccinate Lijun Group 100

[0034] Hydroxypropyl Beta Cyclodextrin Shaanxi Institute of Microbiology 500

[0035] Total 600

[0036] Add hydroxypropyl beta-cyclodextrin to 5ml of medicinal absolute ethanol under stirring conditions, and continue to stir until completely dissolved; add ethylsuccinate and stir until completely dissolved; ultrasonically treat in an ice bath for 10 minutes; the resulting solution Filtered through a sterilized 0.2mm nylon membrane; after being freeze-dried, it can be packaged for use.

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Abstract

A medicine in the form of water-soluble powder is prepared from erythromycin ethylsuccinate and hydroxy-beta-cyclodextrin through proportional mixing and freeze drying. It is applied by intravenous injection or intramuscular injection.

Description

technical field [0001] The invention belongs to the improvement of the dosage form of erythromycin containing ethylsuccinate, and relates to the technical field of medicine. Background technique [0002] Erythromycin Ethylsuccinate (Erythromycin Ethylsuccinate) chemical name erythromycin 2'-ethyl succinate; molecular formula: C 43 h 75 NO 16 , Molecular weight: 862.07, belonging to macrolide antibiotics, is a new generation of broad-spectrum antibacterial anti-inflammatory drugs, has been included in the US Pharmacopoeia, European Pharmacopoeia and Chinese Pharmacopoeia (2000 edition). Its greatest feature is its broad antibacterial spectrum and wide range of medication, and is suitable for various inflammations, especially for patients with allergies and drug resistance to penicillins and cephalosporins. Ethrythromycin ethylsuccinate has definite curative effect and rapid action, especially for upper respiratory tract infections caused by atypical pathogens such as Legio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7048A61P31/04
Inventor 杨国武李皎汪大敏赵兰云刘清利
Owner MICROBIOLOGY INST OF SHAANXI
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