Production process of N-acetylamino gluceo metho aldehyde acetal
A technology of glucosamine and glucosamine hydrochloride, applied in the direction of acyclic sugar, etc., can solve the problems of low yield and complicated process, and achieve the effects of high product yield, high product purity and simple production method
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[0014] A production method of N-acetylglucosamine methylal, comprising the following steps in turn:
[0015] ① Neutralize glucosamine hydrochloride with methanol and sodium methoxide acid binding agent for 15-30 minutes (example 15, 20, 25, 30 minutes), and desalt to obtain glucosamine. The weight ratio of methanol to sodium methoxide in the acid-binding agent is 1:2-4 (eg 1:2, 1:3, 1:4). The consumption of acid binding agent is 20~40% (for example 20%, 30%, 40%) of glucosamine hydrochloride by weight.
[0016] ② Carry out acetylation reaction of glucosamine and acetic anhydride to obtain N-acetylglucosamine; the temperature of acetylation reaction is 0°C±5°C, and the time is 50-70 minutes (Example 50, 60, 70 minutes).
[0017] ③Refluxing N-acetylglucosamine in the presence of sulfuric acid and methanol at 70-80°C (Example 70, 75, 80°C) for 20-30 minutes (Example 20, 25, 30 minutes) for acetalization reaction , in N-acetylglucosamine formal. During the acetalization reactio...
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