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Persimmon leaf extract and its preparation and its usage

A persimmon leaf extract and the technology of the extract are applied to the persimmon leaf extract and the fields of its preparation and use, which can solve the problems such as inability to be used for human medicine and many impurities, and achieve the effects of low toxicity and high safety.

Active Publication Date: 2004-11-17
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The crude flavonoids obtained by extraction have the function of lowering blood pressure and promoting plant growth. However, the crude extract obtained by this method still has many impurities and cannot be used for human medicine.

Method used

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  • Persimmon leaf extract and its preparation and its usage
  • Persimmon leaf extract and its preparation and its usage
  • Persimmon leaf extract and its preparation and its usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0186] Take 150Kg of dried persimmon leaves, add 3500L of water and decoct twice for 1.5 hours each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.15 (60°C) to obtain 40kg of liquid extract, add 120L of ethanol until the alcohol content reaches 65 %, stand overnight, filter the supernatant for later use; wash the precipitate twice with 85% ethanol, collect the washing liquid, let it stand, absorb the supernatant and combine with the previous supernatant, recycle the ethanol, obtain 6kg of extract, add 80kg of water Dissolve, filter, and extract the filtrate 3 times with 120 L of ethyl acetate, combine the ethyl acetate solution, recycle the ethyl acetate, and add 4 kg of thick paste to dissolve in water, put it on a macroporous resin column (the macroporous resin is polyamide type), and use Wash with water until the eluent is colorless, then elute with 75% ethanol, collect the eluent, recycle the alcohol, and obtain a concentrated s...

Embodiment 2

[0188] Sample No. E50 No. 97 96 98

Embodiment 3

[0190] Take 500Kg of dried persimmon leaves, add 5500L of water and decoct twice for 2.5 hours each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.12 (60°C) to obtain 100kg of liquid extract, add 320L of ethanol until the alcohol content reaches 75 %, filter the supernatant for later use; the precipitate is washed twice with 75% ethanol, the washing liquid is collected, and the ethanol is recovered. The obtained extract is 11.6 kg, dissolved in 150 kg of water, filtered, and the filtrate is extracted 3 times with 320 L of ethyl acetate, combined with acetic acid Ethyl solution, reclaim ethyl acetate, add water to dissolve 14kg thick paste, put on the macroporous resin column (macroporous resin is AB-8 type), wash with water until the eluent is colorless, then elute with 55% ethanol to Colorless, collect the eluent, reclaim the alcohol, and obtain a relative density of 1.13 (60°C) concentrated solution by spray drying under reduced p...

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PUM

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Abstract

The invention discloses a persimmon leaf extract, its preparing process and use, wherein the extract is prepared from the leaves of Diospyros plants through water boiling, alcohol deposition, acetic acid ethyl ester extraction, macropore resin adsorption, ethanol elution, recovering ethanol to obtain the persimmon leaf extract concentration. The extract contains 65-90% (by dried extract) of total flavones, which comprises quercetin and kaempfetol, which account to 8-14% and 12-23% (by dried extract).

Description

technical field [0001] The present invention relates to a medicinal extract derived from plant material, its preparation method and application, in particular to the plant persimmon leaf extract, its preparation method and application. Background technique [0002] Persimmon leaves are bitter in taste and cold in nature. It has the effects of lowering the breath, relieving asthma, quenching thirst, promoting body fluid, and treating sores, and has a wide range of pharmacological effects. Studies at home and abroad have shown that persimmon leaf preparations, persimmon leaf tea, persimmon leaf extracts and persimmon leaf flavonoid glycosides prepared from persimmon leaves have the functions of lowering blood pressure, inhibiting bacteria, lowering blood lipids, lowering cholesterol, hemostasis, promoting blood circulation, removing blood stasis, and inhibiting blood circulation. Various physiological functions such as cancer growth. [0003] There are many compounds contain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/10A61P25/00
Inventor 徐安龙贝伟剑李楚源陈矛彭文烈王德勤陈薇罗杰
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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