Oral disintegrating tablet of bambuterol hydrochloride and its preparation method

Abstract

The invention discloses a Bambuterol Hydrochloride oral disintegration tablet, wherein the principal drug employs Bambuterol Hydrochloride, the auxiliary materials include lactose, mannitol, crystalline cellulose, low replacement methylcellulose propylene glycol ether, cross bonding polyvinyl pyrrolidon, sodium hydrogen carbonate, citric acid, Aspartame, perfume compound, and magnesium stearate. The tablet has good treatment action for bronchial asthma, chronic bronchitis and pulmonary emphysema.

Description

Technical field: [0001] The invention relates to an oral pharmaceutical preparation for treating asthma and a preparation method thereof, in particular to a bambuterol hydrochloride orally disintegrating tablet capable of rapidly disintegrating, releasing and masking bad smell and a preparation method thereof. Background technique: [0002] Babuterol hydrochloride is a long-acting β2-receptor stimulant and is currently the longest-acting bronchodilator. After oral administration, it can be preferentially distributed in the lung tissue, and slowly hydrolyzed in the lung tissue to produce terbutaline, thereby maintaining a balanced and continuous plasma concentration in the blood. Oral once a night, the action time can reach 24 hours. [0003] Babuterol hydrochloride is a new generation of asthma medicine, which has the advantages of super long-acting, small side effects, and convenient administration. It has great medical value for asthma patients who are prone to attacks at...

AI Technical Summary

Problems solved by technology

[0004] At present, although bambuterol hydrochloride has various oral dosage forms, it is not very convenient for the elderly and children who have certain difficulties in swallowing

For example: In the case of tablets and capsules commonly used as oral preparations, many elderly people and children with poor swallowing ability are reluctant to take these solid dosage forms, complaining of difficulty swallowing medicine or esophageal obstruction, while chewable tablets are also It is also not suitable for the elderly and children with weak chewing ability

As far as powders or granules are concerned, in addition to their difficulty in swallowing, they are also easy to stay in the mouth, resulting in an unpleasant feeling in the mouth. At the same time, drinking water is required when taking the above oral preparations, especially the elderly and children need to take a lot of water However, drinking too much water will affect the night rest of the elderly and children

Syrup was once considered an ideal dosage form for the elderly and children, but for many elderly and infirm patients, they still cannot get liquid preparations into their mouths, and there are still many problems in use, and many oral drugs have a bitter taste and bad smell are often unacceptable. Some patients refuse treatment in order to avoid taking this medicine, which leads to delaying the best time for treatment.

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