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Application of 3-hydroxyphenyl phthale compound in preparing culicifuge

A technology of hydrocarbyl phthalides and compounds, which is applied in the application field of 3-hydrocarbyl phthalides in the preparation of mosquito repellents, can solve problems such as no breakthrough progress, and achieve the effect of low toxicity and low cost

Inactive Publication Date: 2004-05-19
谢秀琼 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The search for new repellents in the United States has not made breakthroughs. Researchers believe that there is no compound that has all the advantages of Deet without its disadvantages

Method used

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  • Application of 3-hydroxyphenyl phthale compound in preparing culicifuge
  • Application of 3-hydroxyphenyl phthale compound in preparing culicifuge
  • Application of 3-hydroxyphenyl phthale compound in preparing culicifuge

Examples

Experimental program
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Effect test

specific Embodiment approach

[0034] The medicinal materials Chuanxiong, Angelica, Ligusticum, and Celery contain a variety of 3-hydrocarbylphthalides (see references 1 to 4), which can be extracted from the above plants by steam distillation, CO2 supercritical extraction, and organic solvent extraction. Separation and extraction can also be used to obtain some of the compounds by chemical synthesis (the synthesis method can refer to the methods of Chinese patents 92111278 and 99109673). The medicament can be prepared according to the conventional preparation method of various dosage forms of blood-sucking insect repellent.

[0035] Prove the beneficial effect of the present invention below by specific pharmacodynamics test.

experiment example 1

[0036] Experimental Example 1 The attack power test of the tested insects targeted by the mosquito repellent of the present invention

[0037] 1. Test conditions: temperature 26°C±1°C, relative humidity 60%±5%.

[0038] 2. Insects to be tested: Aedes albopictus (♀♀) was prepared according to the relevant requirements of GB / T17322-1998, provided by the insect breeding room of our center.

[0039] 3. Test method: According to the relevant provisions of the indoor efficacy test method for repellents in GB / T17322.1998 "Indoor efficacy evaluation of insecticides for pesticide registration and sanitation".

[0040] 3.1 Aedes albopictus attack force test: Put about 300 Aedes albopictus mosquitoes in a 40cm×30cm×30cm mosquito cage, and then choose 3 people to expose 4cm×4cm skin on the back of their hands, and cover the rest with latex gloves. Put your hands into the mosquito cage for 2 minutes, if more than 30 test insects come to land, the attack force test is qualified, and these ...

experiment example 2

[0050] Experimental example 2 Deet repellent effect test results on Aedes albopictus

[0051] Adopt the test method of test example 1, do mosquito repellent effect test to commercially available DEET (Deet), its result is as the contrast of the mosquito repellent effect of compound of the present invention, see Table 2:

[0052] Table 2 The test results of Deet's repellent effect on Aedes albopictus

[0053] Personnel Number of trials Exposure to mosquitoes Different times in the blank control group Different times after spraying in the test group

[0054] Number (only / cage) Time (min) Number of test insects stopped (only) Number of test insects stopped (only)

[0055] 1h 2h 3h 4h 5h 2h 3h 4h 5h 6h 7h 8h

[0056] 1 300 2 35 40 32 37 41 0 0 0 0 0 3

[0057] 2 300 2 37 35 36 40 40 0 ​​0 0 0 0 2

[0058] 3 300 2 40 35 40 37 40 0 ​​0 0 0 0 3

[0059] It can be seen from Table 5 that the Deet submitted for inspection has a repellent effect on A...

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Abstract

An application of 3-hydroxypyhenyl phthaleine compound is prepared the repellent of hematophagus, such as mosquito, is disclosed. Said compound may be ligusticumic lactonic 3-butylidenephenyl phtaleine, 3-butylphenyl phthaleine, etc.

Description

technical field [0001] The invention relates to the application of 3-hydrocarbyl phthalide compounds in the preparation of hygienic insecticides, in particular to the application of 3-hydrocarbyl phthalide compounds in the preparation of mosquito repellents. technical background [0002] Repellants are effective personal insect repellents, and in some cases, they play an irreplaceable role in protecting against the sting and harassment of blood-sucking insects. Repellants have broad development prospects in both military and civilian applications. Repellent research has always been valued by relevant departments. Some foreign units have never stopped researching. In recent years, research has developed in both depth and breadth. The current research on repellents involves many aspects, such as the test and development of botanical repellents, the evaluation of new compounds, the improvement of testing techniques, the research of mixed formulations an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/08C07D307/33
Inventor 谢秀琼毛羽罗海燕
Owner 谢秀琼
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