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Autonomic soft capsules and producing process thereof

A soft capsule, plant-based technology, applied in the field of components and production technology of medicinal soft capsule film, can solve problems such as the spread of mad cow disease

Inactive Publication Date: 2004-04-21
SHANGHAI ZHONGWEI BIOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although gelatin has good properties in the preparation of soft capsules, gelatin as a heterologous protein may be antigenic
For example, imported bovine-derived gelatin materials may contain prions, and soft capsules made from them may cause the spread of mad cow disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] The method for preparing vegetable soft capsules of the present invention can be carried out with existing equipment for preparing gelatin soft capsules. According to the needs, the drop method, the steel plate molding method, or the rotary molding method and the corresponding existing production equipment can be selected for production. Under the condition of not needing additional equipment, only need to adjust parameters such as temperature, coating film thickness, operating speed according to the formula to prepare the required plant-based soft capsules.

[0041] When adopting dripping method to produce seamless dripping pills, the temperature of glue solution should be maintained at 85-95°C, and the temperature of paraffin oil should be maintained at 10-20°C.

[0042] When the rotary molding method is used for production, the temperature of the rubber box is 85-95°C; the temperature of the wedge-shaped spray body should be 75-80°C, and the outer rubber is heated to...

Embodiment 1

[0052] The production method is as follows: weigh 3.5 grams of κ-type carrageenan, 40 grams of maltose, pour 56.5 grams of deionized water, heat to 90°C, dissolve evenly, keep warm at 92°C for 1-2 hours, and mix the material liquid and medicinal liquid The soft capsules are prepared by dripping or pressing. Dry at about 25°C, and control the water content of the capsule film within 10%-20%.

[0053] The finished capsule film contains 6.84% (according to the total weight of the finished product. The same below) of κ-type carrageenan and 78.17% of maltose. The finally obtained capsules are transparent, good in elasticity and good in mouthfeel.

Embodiment 2

[0056] The production method is: weigh 4 grams of κ-type carrageenan, 24.5 grams of maltose, 0.05 grams of propyl gallate, and 0.05 grams of sodium benzoate, pour 60.4 grams of deionized water, heat to 90 ° C, dissolve evenly, and then add 5 grams of glycerin and Pour 6 grams of polyethylene glycol (PEG400) into it and stir evenly, heat it at 95°C for 1-2 hours, and eliminate air bubbles, and then prepare the soft capsules by dripping or pressing the material liquid and medicinal liquid. Dry at about 35°C, and control the water content of the capsule film within 10%-20%.

[0057] The finished capsule film contains 8.59% (according to the total weight of the finished product, the same below) of κ-type carrageenan, 52.59% of maltose, 10.73% of glycerin, 12.88% of polyethylene glycol (PEG400), and 0.11% of propylene gallate Esters, 0.11% Sodium Benzoate. The finally obtained capsules are transparent, elastic and taste good.

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PUM

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Abstract

A vegetative soft capsule instead of gelatin capsule is prepared from hydrophilic gel, adhesive and water, and features no pollution caused by animal protein. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of materials, in particular to the components and production process of the soft capsule film for medicine. Background technique [0002] At present, the film of the soft capsule is made of gelatin extracted from animal bones or skins such as cattle and pigs, and then added with glycerin fatty acid and sorbitol. Although gelatin has good properties in the preparation of soft capsules, gelatin as a heterologous protein may be antigenic. For example, imported bovine-derived gelatin materials may contain prions, and soft capsules made from them may cause the spread of mad cow disease. With the increasing market demand for plant-derived materials, it is imminent to develop plant-based soft capsule materials other than gelatin. [0003] Therefore, there is an urgent need in this area to develop new plant-based soft capsule materials and production techniques thereof. Contents of the invention [0004] The purpose of t...

Claims

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Application Information

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IPC IPC(8): A61J3/07A61K9/48
Inventor 张士楚尧辉吴懿
Owner SHANGHAI ZHONGWEI BIOCHEM
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