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Biopreparate for healing wounded surface and curing intractable ulcer

A technology for refractory ulcers and wound healing, which can be used in medical preparations containing active ingredients, drug combinations, peptide/protein components, etc., and can solve the problems of high cost and inconvenient clinical use.

Inactive Publication Date: 2004-03-31
武汉格瑞生物工程有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0005] Domestic research and development of such drugs is currently limited to freeze-dried preparations, which are expensive and inconvenient for clinical use

Method used

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Embodiment Construction

[0007] This invention is the first time to successfully solve a series of problems such as the maintenance and activation of biological activity of rh-aFGF finished products in liquid state, thus making it possible for rh-aFGF to be made into clinically simple and easy dosage forms such as aerosol. Its preparation process makes aFGF, heparin, EDTA, Ncel and PB into a pharmaceutical composition according to a certain ratio. The stock solution has stable activity and can be stored naturally for 12 months. The potency of the spray and film preparation is still ≥2.5× 10 4 Activity units / ml. The preparation process is mature and convenient, and the clinical treatment effect is remarkable.

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Abstract

The invention relates to an aerosol preparation produced by restructured human acidic desmocyte growth factor for treating wound surface assimilation and refractoriness ulcer. The preparation by the invention has good stableness and substantial clinical curative effect. íí

Description

technical field [0001] The invention relates to a new preparation for treating wound healing and refractory ulcer with recombinant human acidic fibroblast growth factor (aFGF). Background technique [0002] Wound repair is a basic medical problem. For thousands of years, countless medical experts have made unremitting efforts to find a quick, perfect and simple method. However, until the end of the 1980s, the traditional wound repair method still remained at the debridement , Suture and other treatment measures that passively wait for the repair of the machine parts. [0003] Since the 1990s, with the rapid development of molecular biology and genetic engineering cloning technology, there have been fundamental breakthroughs in the research on wound repair. Studies have shown that when the mechanism is damaged, the tissues or cells around the damaged site will release a variety of endogenous cytokines that can promote healing, such as aFGF, bFGF, EGF, PDGF, etc., in an autoc...

Claims

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Application Information

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IPC IPC(8): A61K38/19A61P17/02
Inventor 李贵玲彭红卫赵斌
Owner 武汉格瑞生物工程有限公司
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