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Biodegradable common bile duct built-in carriage and its making method

A technology of biodegradation and common bile duct, which is applied in the field of biodegradable polymer common bile duct stent and its preparation, can solve the problems of biliary stricture and bile leakage, and achieve the effect of relieving pain, reducing hospitalization costs, and benefiting physical and mental recovery

Inactive Publication Date: 2004-01-28
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Sometimes pancreatic surgery also requires the cutting and re-anastomosis of the common bile duct, which is also prone to bile leakage and biliary stricture

Method used

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  • Biodegradable common bile duct built-in carriage and its making method
  • Biodegradable common bile duct built-in carriage and its making method
  • Biodegradable common bile duct built-in carriage and its making method

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Embodiment

[0029] Take the copolymer PLGA (IA / GA=70 / 30) of L-lactide (LA) and glycolide (GA) synthesized by the laboratory of Changchun Institute of Applied Chemicals, with a molecular weight of about 120,000, in the XSS-300 torque flow Extrude a Φ20mm screw extruder (L / D=25) into a thin tube with an outer diameter of 1.0mm and an inner diameter of 0.6mm, and cut it into a bracket with a length of about 5.5mm. Smaller and rounded at the end. The stent made in this way is ready for use after being sterilized and packaged.

[0030] A total of 110 Wistar rats were selected and divided into control and test groups. Both groups underwent common bile duct exploration surgery. The length of the longitudinal incision was about 2 mm, and it was sutured with 11-0 nylon suture with a needle distance of 0.4-0.5 mm. The control group was sutured directly after probing. In the test group, a stent sterilized with 5% strong iodine was placed through the incision after exploration, and its position wa...

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Abstract

The invention is a kind of main bile duct inner bracket which can be decomposed biologically and the manufacturing method. It is made up from biology-decomposed molecular material and added in the developable ingredient by the X radial. It uses the anatomy shape of the main bile duct or can be sealed with the duct wall, it can locate precisely and will not glide. The tube of the bracket has enough size, and the outer wall have several orbicular heave. It can be throat shape which can prvent the leakage of bile. The manufacturing process includes: (1) blending the biology-decomposed molecular with X-radial developing ingredient and assistant and makes them into particles. (2) carries on injection shaping, and the shape decoration. It can replace the T tube in bile duct operation.

Description

technical field [0001] The invention relates to a biodegradable polymer common bile duct built-in stent and a preparation method thereof. technical background [0002] Common bile duct exploration (CBDE) is a relatively frequent general surgery for the treatment of biliary stones, biliary stricture and other diseases. When the common bile duct is explored, a longitudinal incision is generally made on the common bile duct, and the incision is sutured after the exploration is completed. However, simple sutures are prone to bile outflow or biliary stricture, which can cause related complications. Therefore, a "T-tube" is often placed clinically. It plays a supporting role during the operation and keeps the biliary tract unblocked after the operation. Bile or other secretions can flow to the intestinal tract and flow out from the long arm of the T-tube, avoiding complications caused by biliary stricture and cholestasis. The gap between it and the wall of the common bile duct i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61F2/04
CPCA61F2002/041A61F2210/0004A61F2/04
Inventor 景遐斌刘铜军陈学思刘韶晖徐效义边新超李有柱张凯
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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