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Aqueous liquid preparation

An aqueous solution and sulfonamide technology, applied in the directions of non-central analgesics, anti-inflammatory agents, organic active ingredients, etc., can solve problems such as instability to light

Inactive Publication Date: 2003-08-27
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is such a problem with pranoprofen, it is not stable to light in aqueous solution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Aqueous solutions of eye drops are prepared in a conventional manner according to the following formulations.

[0051] Pranoprofen 0.05g

[0052] Sulfamethoxazole 4.0g

[0053] Sodium edetate 0.001g

[0054] Sodium hydroxide q.s.

[0055] Sterilized purified water ad 100ml

[0056] pH 8.3

Embodiment 2

[0058] Aqueous solutions of eye drops are prepared in a conventional manner according to the following formulations.

[0059] Pranoprofen 0.05g

[0060] Sulfamethoxazole 4.0g

[0061] Dipotassium Glycyrrhizinate 0.1g

[0062] Sodium edetate 0.001g

[0063] Sodium hydroxide q.s.

[0064] Sterilized purified water ad 100ml

[0065] pH 8.3

Embodiment 3

[0067] Aqueous solutions of eye drops are prepared in a conventional manner according to the following formulations.

[0068] Pranoprofen 0.05g

[0069] Sulfaisoxazole 4.0g

[0070] Sodium edetate 0.001g

[0071] Sodium hydroxide q.s.

[0072] Sterilized purified water ad 100ml

[0073] pH 8.3

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PUM

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Abstract

The present invention provides an aqueous solution containing pranoprofen or a pharmacologically acceptable salt thereof, and a sulfa drug, and a method for making pranoprofen or a pharmacologically acceptable salt thereof stable to light in an aqueous solution, which includes adding a sulfa drug to the aqueous solution containing pranoprofen or a pharmacologically acceptable salt thereof.

Description

technical field [0001] The present invention relates to the aqueous solution containing pranoprofen or its pharmacologically acceptable salt, and sulfonamide drug. Furthermore, the present invention relates to a method for stabilizing pranoprofen or a pharmacologically acceptable salt thereof against light in an aqueous solution, the method comprising adding a sulfa drug. Background technique [0002] Pranoprofen (chemical name: α-methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid) is a non-steroidal anti-inflammatory Effective for inflammatory diseases of the anterior segment of the eye such as conjunctivitis, keratitis, blepharitis, etc. But pranoprofen has such a problem that it is unstable to light in aqueous solution. As a method for improving the photostability of pranoprofen in an aqueous solution, only one method is known, which method comprises the concomitant use of an antioxidant such as dibutylhydroxytoluene in an aqueous solution of pranoprofen in the prese...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/436A61K47/20A61P27/02A61P29/00C07D239/42C07D239/46C07D261/16C07D491/04C07D491/052
CPCA61K9/0048C07D239/42C07D491/04A61K47/20A61K31/436C07D239/47C07D261/16A61P27/02A61P29/00A61K2300/00A61K31/435
Inventor 中山久幸山﨑夫规子
Owner SENJU PHARMA CO LTD
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