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Method for determining hemodynamic state

A technology of hemodynamics and status, applied in vascular assessment, blood flow measurement, blood pressure measurement devices, etc., can solve problems such as insufficient perfusion

Inactive Publication Date: 2003-06-04
N I MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, in acute Cp i In patients who decline, the SVR i Responses may be either (1) modest - resulting in a compensating or near compensating response, (2) excessive - resulting in a much higher than required increase in MAP and thus pulmonary edema, or (3) insufficient - resulting in low MAP and live organ (brain, heart, kidney) hypoperfusion and cardiogenic shock

Method used

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  • Method for determining hemodynamic state
  • Method for determining hemodynamic state
  • Method for determining hemodynamic state

Examples

Experimental program
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Embodiment 1

[0042] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT Example 1: Determination of Hemodynamic Status by Graphical Method patients and methods

[0043] Hemodynamic data were obtained in patients undergoing right heart catheterization. Inclusion Standard:

[0044] All patients diagnosed with systolic CHF (sCHF), hypertensive crisis, acute pulmonary edema (PE), vasodilatory shock or cardiogenic shock by conventional clinical criteria (see below) were included. Exclusion criteria:

[0045] Significant valvular heart disease, significant bradycardia or tachycardia, or renal failure (creatinine > 2.5 mg / dl). Clinical diagnostic criteria:

[0046] 1) Systolic CHF: Patients consented to invasive hemodynamic evaluation due to exacerbation of CHF, defined as clinical symptoms and signs of CHF, NYHA class III-IV, accompanied by EF <35% on echocardiography And did not use any oral drug treatment for 6 hours or no intravenous drug treatment for the last 2 hours; did not meet the cr...

Embodiment II

[0069] Another embodiment of the process of the invention will now be described by the examples given below. However, it will be clear to those skilled in the art that other embodiments using other statistical analysis methods are also possible. 1. Data statistical methods:

[0070] All parameters of the 5 clinical groups were compared using one-way analysis of variance. The Ryan-Einot-Gabriel-Welsch Multiple Range Test was used for pairwise comparisons between these groups, while Dunnett's T test was used to compare all groups with healthy controls.

[0071] A 1-sample t-test was performed to compare the average wedge pressure of each group with that of normal subjects (less than 12 mmHg).

[0072] To determine the usefulness of hemodynamic parameters to differentiate between clinical syndromes, ROC curves from logistic regression models were applied to the data to determine the best cut-off points for the different parameters, according to highest sensitivity and specifi...

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Abstract

A method for determining the hemodynamic state of a subject. The method comprises (a) determining the cardiac power index (Cpi) and systemic vascular resistance index (SVRi) values of a plurality of patients who have been diagnosed as having a specified hemodynamic state; (b) determining the range of Cpi and SVRi paired values corresponding to each of the hemodynamic states; (c) determining the Cpi and SVRi paired value of the subject; (d) comparing the Cpi and SVRi paired value of the subject to the ranges of Cpi and SVRi paired values determined in step (b); and (e) determining the range of Cpi and SVRi paired values which is most similar to the Cpi and SVRi paired value of the subject. The hemodynamic state which corresponds to the range indicates the hemodynamic state of the subject.

Description

field of invention [0001] The present invention relates to the use of performance parameters of the heart and peripheral vessels to determine the hemodynamic state of a patient. Background of the invention [0002] The following documents may be relevant to the understanding of the present invention and are referred to by numbers in this specification: [0003] 1. Roul G, Moulichon M.E., Bareiss P, Gries P, Koegler A, SacrezJ, Germain P, Mossard J.M., Sacrez A, Prognostic factors of chronicheart failure in NYHA class II or III: value of invasive exercisehaemodynamic data. Eur Heart J( 1995); 16:1387-98. [0004] 2. Marmor A, Schneeweiss A. Prognostic value of noninvasively obtained left ventricular contractile reserve in patients with severe heart failure. J Am Coll Cardiol (1997) Feb; 29(2): 422-8. [0005] 3. Marmor A, Jain D, Cohen LS, Nevo E, Wackers FJ, Zaret BL. Left ven tricular peak power during exercise: a noninvasive approach for assessment of contractile reserve...

Claims

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Application Information

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IPC IPC(8): A61B5/0245A61B5/021A61B5/0215A61B5/026A61B8/04A61B10/00
CPCA61B8/04A61B5/021A61B5/02028G06F19/3431A61B5/0215A61B5/02007G16H50/30
Inventor D·古尔G·科特Y·莫什克维茨
Owner N I MEDICAL
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