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Composition of paeoniflorin and albiflorin and its preparation method

A technology of paeoniflorin and paeoniflorin, which is applied in the field of medicine and achieves standardized and modernized and reliable effects

Inactive Publication Date: 2003-04-30
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no uniform standard for the extract of Paeoniae Alba. The total glucosides of paeony capsules on the market are preparations made from the effective parts extracted from the traditional Chinese medicine Paeoniae Alba. It has pharmacological effects such as anti-inflammatory and immune regulation. Rheumatoid Arthritis Treatment

Method used

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  • Composition of paeoniflorin and albiflorin and its preparation method
  • Composition of paeoniflorin and albiflorin and its preparation method
  • Composition of paeoniflorin and albiflorin and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 10Kg of dried peony slices were extracted by boiling water for 2 times, each time for 2 hours. The extract was filtered and passed through a reverse adsorption resin column, and then eluted with alcohol water. After the eluate was concentrated, it was chromatographed on an alumina column to obtain The components of paeoniflorin and paeonifloride were finally obtained through silica gel column chromatography to obtain 150 g of the composition described in this patent (hereinafter referred to as the composition).

Embodiment 2

[0032] 50g of this composition is mixed with 45g of microcrystalline cellulose and 5g of magnesium stearate, and the mixture is used for tableting, each tablet weighs 0.2g, and each tablet contains 0.1g of this composition. According to the symptoms, take 1-2 tablets each time, 2-3 times a day.

Embodiment 3

[0034] 50g of this composition, and 50g of cornstarch, add water to make a soft material, pass through a 12-mesh sieve to granulate, dry to obtain granules, and put them into capsules. The content of each capsule weighs 0.2g and contains 0.1g of this composition. According to the symptoms, take 1-2 tablets each time, 2-3 times a day.

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Abstract

A composition of paeoniflorin and albiflorin is prepared from peony through extracting in water to obtain aqueous solution, resin adsorption, alcohol eluting, concentrating, and chromatography by alumina column and silica gel column. It can be used to prepare to medicines in different forms.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a composition of paeoniflorin and paeonifloride glycoside and a preparation method thereof. Background technique: [0002] Peony is the dried root of the perennial herbaceous plant of Paeoniaceae Paeoniaceae in Ranunculaceae. The so-called white peony and red peony (Paeonia lactifora Pall, P. veitchii Lynch and P. obovata Maxim), according to the current application situation and the records in past materia medica, it can be considered that the white peony is the root of the cultivated peony plant, and the red peony is mainly from the wild peony. root. [0003] Peony is slightly cold in nature, bitter and sour in taste, and has the functions of nourishing blood and softening the liver, relieving pain in the middle, astringing light and sweating. "The Classic" records: "mainly evil abdominal pain, remove blood and phlegm, break firm accumulation, cold and heat hernia, relieve ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/16A61P25/20A61P29/00A61P37/02
Inventor 游松梁士民任杰吕显刚赵晓丹刘艳秋
Owner SHENYANG PHARMA UNIVERSITY
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