Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Prepn apparatus and process for 2-fluoro-18 substituent-2 deoxy-beta-D-glucose

A glucose and equipment technology, applied in the field of positron radiopharmaceutical preparation, can solve the problems of low synthesis efficiency, inconvenient operation, complicated equipment, etc., and achieve the effects of easy control and operation, simplified equipment, and reduced radioactive loss

Inactive Publication Date: 2003-02-26
派特(北京)科技有限公司
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the existing problems of complex equipment for preparing 2-fluoro-18-generation-2-deoxy-β-D-glucose, inconvenient operation and low synthesis efficiency, and adopts the following technical solutions to solve them:

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Prepn apparatus and process for 2-fluoro-18 substituent-2 deoxy-beta-D-glucose
  • Prepn apparatus and process for 2-fluoro-18 substituent-2 deoxy-beta-D-glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0020] Such as figure 1 As shown, the equipment for preparing 2-fluoro-18-generation-2 deoxy-β-D-glucose includes a reaction bottle 23, liquid addition bottles 11, 12, 13, 14, 15, 16 communicated with the reaction bottle 23 through conduits, anion One end of the column QMA 10 is connected to the liquid addition bottle 11 and the target source through the three-way valve 1, and the other end is connected to the reaction bottle 23 and the waste collection bottle through the three-way valve 2. The reaction bottle and each liquid addition bottle are connected with a pneumatic Valves 3, 4, 5, 6, 7, 8, 9, reaction bottle 23 communicate with product collection bottle 21 through purification column and filter membrane 20, and purification column is AG11A8 column 17, C-18 column 18 and Alumin column 19 successively, Said reaction bottle 23 is placed o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to the field of preparing positive electronic radioactive medicine, especially the preparation apparatus and process of 2-fluoro-8 substituent-2-deoxy-beta-D-glucose. The apparatus includes wind bath for heating and cooling the reaction bottle, and negative perssure transmission unit for ultimate product with reduced radioactivity loss, shortened time and raised synthesis efficiency. The technological process combined acid-alkali hydrolysis without possibility of elimination reaction in the 2-position, and it has short hydrolysis period and high radioactive purity and chemical purity of the prepared medicine.

Description

technical field [0001] The invention relates to the field of preparation of positron radiopharmaceuticals, in particular to a radiopharmaceutical 2-fluoro-18-generation-2deoxy-β-D-glucose ( 18 F-FDG) manufacturing equipment and process. Background technique [0002] 18 F-FDG is the most widely used radiopharmaceutical in PET research. It is widely used in the diagnosis of malignant tumors, the determination of glucose metabolism in the myocardium and brain, etc. Due to its importance and wide applicability, since its synthesis was first reported in 1977, many literatures have reported 18 F-FDG preparation, and developed a variety of automated synthesis equipment. At present, everyone adopts the selective stereonucleophilic reaction reported by Hamacher K in 1986, and can choose to synthesize 2-fluoro-18 generation-2 deoxy-β-D-glucose (Hammacher K, J NuclMed, 27, 235 (1986), p235-238). [0003] The F-18 ion becomes a naked ion after K2.2.2 complex...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/08
Inventor 张锦明田嘉禾于生民
Owner 派特(北京)科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com