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Medicinal composition for treating parafunctional metrorrhagia and its preparation method

A technology for treating function and uterine bleeding, applied in the direction of drug combination, medical formula, drug delivery, etc., can solve the problems of unclear indications, inability to determine indications, lack of coordination, etc., and achieve the effect of enhancing blood circulation and dredging menstruation

Active Publication Date: 2007-04-04
RONGCHANG PHARM ZIBO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently available medicines for the treatment of dysfunctional uterine bleeding are Chinese medicines and relatively few related reports, such as "264 Cases of Syndrome Differentiation Treatment of Dysfunctional Uterine Bleeding" (Journal of Practical Traditional Chinese Medicine, Volume 17, No. 3, Page 173, 2003) The treatment of this disease has only been summarized by simple classification; the invention patent application with application number 03113819.5 discloses a prescription using the treatment method of "clearing heat and cooling blood, promoting blood circulation and removing blood stasis"; the invention patent with patent number 98112907.2 also discloses A kind of prescription, indications include three types of blood stasis, blood deficiency, and blood heat. Actually, from the perspective of the prescription, although it contains various drugs for the above types of symptoms, it is difficult to distinguish the primary and secondary among these drugs. Coordination, resulting in unclear indications
There are other drug combinations, and its indications cannot even be determined, so there is no reference

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0027] Experimental Example 1: Pharmacodynamics Experiment

[0028] 1. Test materials

[0029] (1) Test drug: Kunning Oral Liquid (hereinafter referred to as Kunning Liquid), batch number 920722, 10ml of oral liquid per bottle, containing 1.25g of crude drug per ml. The experimental dose is calculated based on the amount of crude drug. The excipients contain 20% sucrose and 0.3% benzoic acid, which are prepared into a solution with distilled water.

[0030] (2) Positive control drug: Wuji Baifeng oral liquid (hereinafter referred to as Wuji liquid), produced by Guangzhou Baiyunshan Pharmaceutical Factory and Guangdong Chaozhou Hongxing Pharmaceutical Factory, with batch numbers 920207 and 941235, respectively. Yunnan Baiyao, produced by China's Yunnan Baiyao Factory and Yunnan Dali Pharmaceutical Factory, the batch numbers are 9307-163 and 950649, respectively. The above drugs were diluted with distilled water before use.

[0031] (3) Other reagents: oxytocin (Oxy), produce...

experiment example 2

[0064] Experimental Example 2: Clinical Research Trial

[0065] The clinical trial protocol is formulated in accordance with the "Guiding Principles for Clinical Research of New Chinese Medicines for Irregular Menstruation" and "Guiding Principles for Clinical Research of New Chinese Medicines for Dysfunctional Uterine Hemorrhage" in the "Guiding Principles for Clinical Research of New Chinese Medicines". There are two phases of clinical trials. That is, the controlled treatment trial phase and the expanded controlled treatment trial phase were carried out simultaneously. A treatment group and a control group were randomly established in a ratio of 1:1, and an open case group was established. A total of 482 patients were observed, including 302 cases in the treatment group and 180 cases in the control group (100-101 cases in each observation and treatment group for each disease, and 60 cases in the control group). The test results show that the hemostatic efficacy of this pro...

Embodiment 1

[0069] Embodiment 1: the preparation of oral liquid

[0070] Prescription composition: Motherwort 30 kg, Angelica 30 kg, Radix Paeoniae Rubra 30 kg, Salvia miltiorrhiza 30 kg, Curcuma 20 kg, Achyranthes bidentata 30 kg, Citrus aurantium 20 kg, Woody fragrance 10 kg, Nepeta (fried charcoal) 20 kg, dry Ginger (fried charcoal) 10 kg, madder 20 kg

[0071] Technological process: Take angelica, turmeric, aurantium, and woody, add water to distill, collect aromatic water, and refrigerate for later use. Soak the dregs of motherwort, red peony root, salvia miltiorrhiza, achyranthes bidentata, Nepeta charcoal, dried ginger charcoal, and madder in water for 2.5 hours, then add 8 times the amount of water to decoct 3 times, the first time for 2 hours, and the second time for 1.5 hours 1 hour for the third time, the decoction and the distilled medicinal liquid were combined, filtered, concentrated to a relative density of 1.14-1.16 (80°C), let cool, added ethanol to make the alcohol cont...

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PUM

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Abstract

A Chinese medicine for treating the metrorrhagia caused by functional disorder is prepared from 11 Chinese-medicinal materials including motherwort, Chinese angelica root, red peony root, red sage root, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating dysfunctional uterine bleeding and a preparation method thereof. The pharmaceutical composition is prepared by taking Chinese herbal medicine as a raw material and adding an appropriate amount of pharmaceutical flavoring agent or / and pharmaceutical excipients. Compound preparations. Background technique [0002] Dysfunctional uterine bleeding is a common disease in gynecology, which not only affects the normal life of patients, but also may lead to anemia, reproductive tract infection, pelvic inflammatory disease and other diseases. Therefore, the treatment of this disease is of great significance. Western medicine has no definite drug for the treatment of this disease, and hormones or antibiotics are used for symptomatic treatment. Traditional Chinese medicine believes that the occurrence of this disease can be caused by qi deficiency, qi stagnation, blood heat, and blood stasis. Ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K36/75A61K36/74A61K36/71A61K36/538A61K36/53A61K36/285A61K36/232A61K36/21A61K9/08A61K9/16A61K9/20A61K9/48A61P15/00A61P7/04
Inventor 杨晓生王海波张永光
Owner RONGCHANG PHARM ZIBO CO LTD
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