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Micro channel array type biological chip by utilizing photon particle coding and method of use thereof

A biochip and microchannel technology, applied in instruments, measuring devices, scientific instruments, etc., can solve the problem of high cost and achieve the effects of low cost, fast hybridization speed, and large amount of encoded information

Inactive Publication Date: 2007-01-17
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the cost of this method is relatively high

Method used

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  • Micro channel array type biological chip by utilizing photon particle coding and method of use thereof
  • Micro channel array type biological chip by utilizing photon particle coding and method of use thereof
  • Micro channel array type biological chip by utilizing photon particle coding and method of use thereof

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Embodiment Construction

[0017] The photonic crystal microsphere coded microchannel array biochip of the present invention is composed of a microchannel 1, a sample inlet 2, a photonic crystal microsphere 3, and a sample outlet 4. Probe molecules are fixed on the photonic crystal microsphere 3. The crystal particles 3 are arranged in the microchannel 1 according to the set order, and the two ends of the microchannel 1 are respectively the sample inlet 2 and the sample outlet 4, wherein the inner diameter of the end of the sample outlet 4 is smaller than the inner diameter of the sample inlet, and its size is It is designed to allow biomolecules to pass through, while blocking the photonic crystal carrier 3 in the microchannel 1, so as to prevent the probes fixed on it from flowing out of the channel. The photonic crystal microspheres 3 immobilized with probe molecules are photonic crystal particles of different colors, and one kind of probe is immobilized on the photonic crystal particles of each color...

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Abstract

It is micro-path array biological chip by use of photon particle code, which is a high-flux detection chip for multiple proteins and genes in the biology sample. The photon crystal micro ball 3 of the chip is located with probe molecule and distributes on the designed order in the micro path 1 with sample-in mouth 2 and sample-out 4, wherein, the sample-out mouth has a smaller radium than that of sample-in mouth and blocks the photon particle in the micro path 1. When in use, it separately connects multiple-position sample valve 5 with sample-in mouth 2 and sample-out mouth 4 through micro peristaltic pump 6 and T shaped pipe 7 to form a seal cross-breed reaction path.

Description

technical field [0001] The invention is a fast, convenient and cheap high-throughput detection chip used for detection of multiple proteins and genes in biological samples. It can be widely used in clinical detection, drug screening, detection of biological samples in the environment, forensic identification, customs inspection and quarantine of agricultural products import and export, gene sequence and functional analysis, and detection of various deadly or pathogenic microorganisms in military bacterial warfare. Background technique [0002] Rapid and high-throughput detection of various protein and DNA sequences in biological samples related to various human diseases, health and important life activities in scientific research and clinical testing, drug screening and environmental testing, etc. Provide guidance and reference for prevention, diagnosis, treatment and life science research. Biochip is a high-throughput biological detection technol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68G01N33/533G01N30/50
Inventor 顾忠泽刘兆斌赵祥伟张宏陆祖宏
Owner SOUTHEAST UNIV
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