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Fixed lipase catalyzed synthesis of fatty acid low carbon alcohol ester

A technology of immobilizing lipase and synthesizing fatty acids, which is applied in fermentation and other fields, can solve the problems of complex operation, high cost, and easy clogging of membranes, and achieve the effects of strong reaction specificity, reduced production costs, and fewer by-products

Inactive Publication Date: 2006-10-11
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The membrane reactor has high catalytic efficiency and can selectively remove the water generated in the reaction, but the membrane reactor also has problems such as high cost, complicated operation, and easy clogging of the membrane.

Method used

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  • Fixed lipase catalyzed synthesis of fatty acid low carbon alcohol ester

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 0.12 g of immobilized enzyme (9000 U / g) was added to 5 mL of organic solvent containing 1 g of palmitic acid (0.54 mol / L) and 0.5 g of 2-ethylhexanol (0.7 mol / L). Under the condition of 40°C, the shaking reaction (190r / min) was performed for 24 hours, and the reaction conversion rate reached 91%.

Embodiment 2

[0033]0.12 g of immobilized enzyme (9000 U / g) was added to 5 mL of organic solvent containing 1 g of palmitic acid (0.54 mol / L) and 0.67 g of 2-ethylhexanol (0.7 mol / L). Under the condition of 40°C, the reaction was shaken (190r / min), and the conversion rate reached 96.7% in 22 hours. The half-life is up to 150hr.

Embodiment 3

[0035] 0.12g of immobilized enzyme (9000U / g) was added to 5mL of organic solvent containing 1g of stearic acid (mol / L) and 0.62g of 2-ethylhexanol (0.65mol / L). Under the condition of 37°C, the reaction was shaken (190r / min), and the conversion rate reached 95% in 24 hours.

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Abstract

The invention uses immobilized microbial lipase to catalyze the synthesis of fatty acid lower alcohol esters in a non-aqueous phase system. Lipase is immobilized on an inert carrier film or textile, and the immobilized carrier can be combined with a wire mesh to form a new type of reactor, which catalyzes the esterification reaction of fatty acids and alcohols in the organic phase within the range of 20-60 ° C, 14 -24hr esterification rate can reach 90-97%. Compared with the current industrial process of esterification using chemical catalysts under high temperature and high pressure, this method has the advantages of mild reaction conditions, low energy consumption, strong reaction specificity and less by-products. Compared with similar enzymatic synthesis processes, the method has the characteristics of easy separation of the product from the immobilized enzyme, which is beneficial to continuous production and easy recovery and repeated use of the immobilized enzyme. At the same time, adding a water-absorbing agent during the reaction can shorten the reaction time and increase the esterification rate. The product transformed by the method has light color and high quality, and has important applications in the fields of energy, agriculture, textile, plastics, food, cosmetics and the like.

Description

(1) Technical field [0001] The invention relates to biochemical industry, in particular to a method for catalyzing the reaction of fatty acid and 9-alcohol to synthesize ester by using immobilized microbial lipase in a non-aqueous phase system. (2) Background technology [0002] Fatty acid esters are commonly used chemical substances in many industries such as food, textiles, plastics, and cosmetics. Fatty acid lower alcohol esters are one of the important industrial additives and surfactants. Aryl esters of short-chain fatty acids are important components of synthetic flavors and main raw materials for flavoring liquor. The low-carbon alcohol esters of long-chain fatty acids such as isooctyl palmitate, isopropyl ester, isopropyl myristate and octyl stearate are important oily raw materials for high-end cosmetics. This kind of long-chain fatty acid ester has good compatibility with skin, has good moisturizing and softening effects, and is widely used in bath products, hair...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/64
Inventor 谭天伟陈必强叶华邓利
Owner BEIJING UNIV OF CHEM TECH
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